Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea
Tuberculosis (TB) is an ongoing global health problem, including in South Korea. To manage TB efficiently, it is necessary to understand the epidemiology, transmission route, and characteristics of prevailing Mycobacterium tuberculosis strains. In this study, we investigated microevolutions over tim...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/8874309 |
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| author | Seung-Eun Song Dong Hyeok Kim Seong-Han Kim Mi-Sun Park Sang-Hee Park Kil-Soo Lee |
| author_facet | Seung-Eun Song Dong Hyeok Kim Seong-Han Kim Mi-Sun Park Sang-Hee Park Kil-Soo Lee |
| author_sort | Seung-Eun Song |
| collection | DOAJ |
| description | Tuberculosis (TB) is an ongoing global health problem, including in South Korea. To manage TB efficiently, it is necessary to understand the epidemiology, transmission route, and characteristics of prevailing Mycobacterium tuberculosis strains. In this study, we investigated microevolutions over time in the spoligotype patterns of M. tuberculosis isolated from TB patients in Korea. We collected 1,055 clinical M. tuberculosis isolates from 16 provinces in Korea from 1994 to 2006 and analyzed them by spoligotyping. We observed 26 subfamilies, including two large predominant families: a Beijing family (72.7%) and the T family (19.1%). Specifically, the abundance of spoligotype SIT269 from the Beijing-like subfamily significantly increased in the 2000s relative to the 1990s in Korea. This study provides an overview of the M. tuberculosis genotype trends over time in Korea. These data also indicate that we should consider the influence of the newly growing SIT269 subtype identified in the Beijing family. |
| format | Article |
| id | doaj-art-8ac1ffc568b34da9b06d6d4f2c009a88 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-8ac1ffc568b34da9b06d6d4f2c009a882025-08-20T03:37:33ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/88743098874309Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in KoreaSeung-Eun Song0Dong Hyeok Kim1Seong-Han Kim2Mi-Sun Park3Sang-Hee Park4Kil-Soo Lee5Division of Bacterial Disease, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of KoreaDivision of Bacterial Disease, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of KoreaDivision of Bacterial Disease Research, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of KoreaSejong Institute of Health and Environment, 12 Seobukbu 2-ro Jochiwon-eup, Sejong-si, Republic of KoreaClinical Research Center, Masan National Tuberculosis Hospital, Gyeongnam, Republic of KoreaDivision of Bacterial Disease Research, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju-si, Chungcheongbuk-Do 28159, Republic of KoreaTuberculosis (TB) is an ongoing global health problem, including in South Korea. To manage TB efficiently, it is necessary to understand the epidemiology, transmission route, and characteristics of prevailing Mycobacterium tuberculosis strains. In this study, we investigated microevolutions over time in the spoligotype patterns of M. tuberculosis isolated from TB patients in Korea. We collected 1,055 clinical M. tuberculosis isolates from 16 provinces in Korea from 1994 to 2006 and analyzed them by spoligotyping. We observed 26 subfamilies, including two large predominant families: a Beijing family (72.7%) and the T family (19.1%). Specifically, the abundance of spoligotype SIT269 from the Beijing-like subfamily significantly increased in the 2000s relative to the 1990s in Korea. This study provides an overview of the M. tuberculosis genotype trends over time in Korea. These data also indicate that we should consider the influence of the newly growing SIT269 subtype identified in the Beijing family.http://dx.doi.org/10.1155/2020/8874309 |
| spellingShingle | Seung-Eun Song Dong Hyeok Kim Seong-Han Kim Mi-Sun Park Sang-Hee Park Kil-Soo Lee Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea |
| title_full | Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea |
| title_fullStr | Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea |
| title_full_unstemmed | Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea |
| title_short | Spoligotype Variation of Mycobacterium tuberculosis Strains Prevailing in Korea |
| title_sort | spoligotype variation of mycobacterium tuberculosis strains prevailing in korea |
| url | http://dx.doi.org/10.1155/2020/8874309 |
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