Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database
Abstract Objective This study aimed to evaluate the association between the Endothelial Activation and Stress Index (EASIX) and 30-day mortality risk in acute myocardial infarction (AMI) patients. Methods Using a retrospective cohort design, data were extracted from the Medical Information Mart for...
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BMC
2024-12-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04353-5 |
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| author | Mingmin Sang Xiaofeng Ma Fangyi Zhu Cunkui Zhu Zuohua Ying |
| author_facet | Mingmin Sang Xiaofeng Ma Fangyi Zhu Cunkui Zhu Zuohua Ying |
| author_sort | Mingmin Sang |
| collection | DOAJ |
| description | Abstract Objective This study aimed to evaluate the association between the Endothelial Activation and Stress Index (EASIX) and 30-day mortality risk in acute myocardial infarction (AMI) patients. Methods Using a retrospective cohort design, data were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database between 2008 and 2019. Patients diagnosed with AMI at intensive care unit (ICU) admission were included. EASIX score was calculated as follows: lactate dehydrogenase (LDH) level (U/L) × creatinine level (mg/dL)/platelet count (109/L). Cox regression models assessed the association between EASIX and 30-day mortality, with subgroup analyses based on age, gender, AMI subtype, and sepsis status. Results A total of 1,036 patients were analyzed, among whom 323 did not survive beyond 30 days post-ICU admission. Higher EASIX scores were associated with increased 30-day mortality in AMI patients [Hazard ratio (HR): 1.70, 95% confidence interval (CI): 1.17–2.46, P = 0.005). Subgroup analyses supported these findings and revealed significant interactions between EASIX and variables such as gender and AMI subtype (P < 0.05). Conclusion Elevated EASIX scores are significantly correlated with increased 30-day mortality risk in AMI patients, suggesting EASIX as a valuable prognostic tool that may inform clinical management strategies to improve outcomes in AMI. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-8abe266c81ec46538e033acafdd0e236 |
| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-8abe266c81ec46538e033acafdd0e2362025-08-20T02:20:48ZengBMCBMC Cardiovascular Disorders1471-22612024-12-0124111010.1186/s12872-024-04353-5Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV databaseMingmin Sang0Xiaofeng Ma1Fangyi Zhu2Cunkui Zhu3Zuohua Ying4Department of Arrhythmia II, Qinghai Provincial Cardio-Cerebrovascular Disease Specialist HospitalDepartment of Arrhythmia II, Qinghai Provincial Cardio-Cerebrovascular Disease Specialist HospitalDepartment of Arrhythmia II, Qinghai Provincial Cardio-Cerebrovascular Disease Specialist HospitalDepartment of Arrhythmia II, Qinghai Provincial Cardio-Cerebrovascular Disease Specialist HospitalDepartment of Arrhythmia II, Qinghai Provincial Cardio-Cerebrovascular Disease Specialist HospitalAbstract Objective This study aimed to evaluate the association between the Endothelial Activation and Stress Index (EASIX) and 30-day mortality risk in acute myocardial infarction (AMI) patients. Methods Using a retrospective cohort design, data were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database between 2008 and 2019. Patients diagnosed with AMI at intensive care unit (ICU) admission were included. EASIX score was calculated as follows: lactate dehydrogenase (LDH) level (U/L) × creatinine level (mg/dL)/platelet count (109/L). Cox regression models assessed the association between EASIX and 30-day mortality, with subgroup analyses based on age, gender, AMI subtype, and sepsis status. Results A total of 1,036 patients were analyzed, among whom 323 did not survive beyond 30 days post-ICU admission. Higher EASIX scores were associated with increased 30-day mortality in AMI patients [Hazard ratio (HR): 1.70, 95% confidence interval (CI): 1.17–2.46, P = 0.005). Subgroup analyses supported these findings and revealed significant interactions between EASIX and variables such as gender and AMI subtype (P < 0.05). Conclusion Elevated EASIX scores are significantly correlated with increased 30-day mortality risk in AMI patients, suggesting EASIX as a valuable prognostic tool that may inform clinical management strategies to improve outcomes in AMI. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-024-04353-5AssociationEndothelial activation and stress indexMortalityAcute myocardial infarction |
| spellingShingle | Mingmin Sang Xiaofeng Ma Fangyi Zhu Cunkui Zhu Zuohua Ying Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database BMC Cardiovascular Disorders Association Endothelial activation and stress index Mortality Acute myocardial infarction |
| title | Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database |
| title_full | Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database |
| title_fullStr | Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database |
| title_full_unstemmed | Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database |
| title_short | Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database |
| title_sort | association between endothelial activation and stress index and 30 day mortality risk in acute myocardial infarction patients a study based on the medical information mart for intensive care iv database |
| topic | Association Endothelial activation and stress index Mortality Acute myocardial infarction |
| url | https://doi.org/10.1186/s12872-024-04353-5 |
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