Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography
Background: Aortic stiffening is a well-known cardiovascular risk factor. Computed tomography (CT) has proven to be a valuable tool in the assessment of aortic elastic properties. Drugs that inhibit the renin-angiotensin system (RAS) play a central role in cardioprotective therapy. We aimed to evalu...
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Elsevier
2024-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724002288 |
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| author | Niya Mileva Panayot Panayotov Irina Hristova Greta Koleva Despina Georgieva Raya Ivanova Dobrin Vassilev |
| author_facet | Niya Mileva Panayot Panayotov Irina Hristova Greta Koleva Despina Georgieva Raya Ivanova Dobrin Vassilev |
| author_sort | Niya Mileva |
| collection | DOAJ |
| description | Background: Aortic stiffening is a well-known cardiovascular risk factor. Computed tomography (CT) has proven to be a valuable tool in the assessment of aortic elastic properties. Drugs that inhibit the renin-angiotensin system (RAS) play a central role in cardioprotective therapy. We aimed to evaluate the relationship between aortic elastic properties and RAS-targeted therapy in hypertensive patients. Methods: This is an observational prospective study of hypertensive patients with nonobstructive coronary artery disease who underwent coronary CT angiography (CCTA). Aortic compliance and distensibility were calculated from the ECG-gated CCTA image. Patients were divided into two groups − those with RAS-targeted therapy − RAS(+) and those with non-RAS-targeted therapy − RAS(−). The elastic properties of the aorta were compared between the two groups. Results: A total of 142 patients were included in the final analysis. 53.5 % of the population were in the RAS(+) group and 46.5 % in the RAS(−) group. Elastic properties of ascending and descending aorta were significantly higher in the RAS(+) group compared to the RAS(−) group: AA compliance 1.42 ± 0.75 mm2/mmHg in the RAS(+) vs 1.03 ± 0.91 mm2/mmHg in the RAS(−), p = 0.024; AA distensibility 2.86 ± 1.11 x10-3mm3 in the RAS(+) vs 1.82 ± 0.97 x10-3mm3 in RAS(−), p < 0.001; DA compliance 1.45 ± 1.10 mm2/mmHg in the RAS(+) vs 1.11 ± 0.91 mm2/mmHg in the RAS(−), p 0.031; DA distensibility 2.35 ± 0.84 x10-3mm3 in the RAS(+) vs 1.73 ± 1.21 x10-3mm3 in RAS(−), p < 0.001. There was an excellent correlation between RAS therapy and ascending aorta compliance and distensibility (r = 0.901, p < 0.001 and r = 0.875, p < 0.001, respectively). Conclusion: Patients receiving RAS-blocking treatment revealed significantly higher compliance and distensibility of ascending and descending aorta. In addition, aortic elastic properties were significantly correlated with the RAS-targeted therapy. |
| format | Article |
| id | doaj-art-8abd617ebc55456c9eabc5414ba1d4e3 |
| institution | OA Journals |
| issn | 2352-9067 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-8abd617ebc55456c9eabc5414ba1d4e32025-08-20T02:07:01ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-12-015510156210.1016/j.ijcha.2024.101562Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomographyNiya Mileva0Panayot Panayotov1Irina Hristova2Greta Koleva3Despina Georgieva4Raya Ivanova5Dobrin Vassilev6Medica Cor Hospital, 1713 Ruse, Bulgaria; Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria; Corresponding author at: Medical University of Sofia, Sofia, Bulgaria.Medica Cor Hospital, 1713 Ruse, Bulgaria; Department of Cardiology, Pulmonology and Endocrinology, Medical Faculty, Medical University of Pleven, BulgariaRuse University “Angel Kanchev”, Ruse, BulgariaRuse University “Angel Kanchev”, Ruse, BulgariaRuse University “Angel Kanchev”, Ruse, BulgariaMedical Faculty, Medical University of Sofia, 1431 Sofia, BulgariaMedica Cor Hospital, 1713 Ruse, Bulgaria; Ruse University “Angel Kanchev”, Ruse, BulgariaBackground: Aortic stiffening is a well-known cardiovascular risk factor. Computed tomography (CT) has proven to be a valuable tool in the assessment of aortic elastic properties. Drugs that inhibit the renin-angiotensin system (RAS) play a central role in cardioprotective therapy. We aimed to evaluate the relationship between aortic elastic properties and RAS-targeted therapy in hypertensive patients. Methods: This is an observational prospective study of hypertensive patients with nonobstructive coronary artery disease who underwent coronary CT angiography (CCTA). Aortic compliance and distensibility were calculated from the ECG-gated CCTA image. Patients were divided into two groups − those with RAS-targeted therapy − RAS(+) and those with non-RAS-targeted therapy − RAS(−). The elastic properties of the aorta were compared between the two groups. Results: A total of 142 patients were included in the final analysis. 53.5 % of the population were in the RAS(+) group and 46.5 % in the RAS(−) group. Elastic properties of ascending and descending aorta were significantly higher in the RAS(+) group compared to the RAS(−) group: AA compliance 1.42 ± 0.75 mm2/mmHg in the RAS(+) vs 1.03 ± 0.91 mm2/mmHg in the RAS(−), p = 0.024; AA distensibility 2.86 ± 1.11 x10-3mm3 in the RAS(+) vs 1.82 ± 0.97 x10-3mm3 in RAS(−), p < 0.001; DA compliance 1.45 ± 1.10 mm2/mmHg in the RAS(+) vs 1.11 ± 0.91 mm2/mmHg in the RAS(−), p 0.031; DA distensibility 2.35 ± 0.84 x10-3mm3 in the RAS(+) vs 1.73 ± 1.21 x10-3mm3 in RAS(−), p < 0.001. There was an excellent correlation between RAS therapy and ascending aorta compliance and distensibility (r = 0.901, p < 0.001 and r = 0.875, p < 0.001, respectively). Conclusion: Patients receiving RAS-blocking treatment revealed significantly higher compliance and distensibility of ascending and descending aorta. In addition, aortic elastic properties were significantly correlated with the RAS-targeted therapy.http://www.sciencedirect.com/science/article/pii/S2352906724002288ComplianceDistensibilityHypertensionAorta |
| spellingShingle | Niya Mileva Panayot Panayotov Irina Hristova Greta Koleva Despina Georgieva Raya Ivanova Dobrin Vassilev Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography International Journal of Cardiology: Heart & Vasculature Compliance Distensibility Hypertension Aorta |
| title | Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| title_full | Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| title_fullStr | Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| title_full_unstemmed | Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| title_short | Impact of renin-angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| title_sort | impact of renin angiotensin system targeted therapy on aortic elastic properties assessed by computed tomography |
| topic | Compliance Distensibility Hypertension Aorta |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724002288 |
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