New and Old Mechanisms Associated with Hypertension in the Elderly
Hypertension is a widely prevalent and important risk factor for cardiovascular diseases that increase with aging. The hallmark of hypertension in the elderly is increased vascular dysfunction. However, the molecular mechanisms by which increased blood pressure leads to vascular injury and impaired...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/150107 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850212085426814976 |
|---|---|
| author | Petra J. Mateos-Cáceres Jose J. Zamorano-León Pablo Rodríguez-Sierra Carlos Macaya Antonio J. López-Farré |
| author_facet | Petra J. Mateos-Cáceres Jose J. Zamorano-León Pablo Rodríguez-Sierra Carlos Macaya Antonio J. López-Farré |
| author_sort | Petra J. Mateos-Cáceres |
| collection | DOAJ |
| description | Hypertension is a widely prevalent and important risk factor for cardiovascular diseases that increase with aging. The hallmark of hypertension in the elderly is increased vascular dysfunction. However, the molecular mechanisms by which increased blood pressure leads to vascular injury and impaired endothelial function are not well defined. In the present paper, we will analyze several mechanisms described in the scientific literature involved in hypertension in the elderly as endothelial dysfunction, increased oxygen delivery to tissues, inflammation, cellular apoptosis, and increased concentration of active metabolites. Also, we will focus on new molecular mechanisms involved in hypertension such as telomeres shortening, progenitor cells, circulating microparticles, and epigenetic factors that have appeared as possible causes of hypertension in the elderly. These molecular mechanisms may elucidate different origin for hypertension in the elderly and provide us with new targets for hypertension treatment. |
| format | Article |
| id | doaj-art-8abcad2703634ac4b91e5e8d858f2a05 |
| institution | OA Journals |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-8abcad2703634ac4b91e5e8d858f2a052025-08-20T02:09:25ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/150107150107New and Old Mechanisms Associated with Hypertension in the ElderlyPetra J. Mateos-Cáceres0Jose J. Zamorano-León1Pablo Rodríguez-Sierra2Carlos Macaya3Antonio J. López-Farré4Cardiovascular Research Unit, Cardiology Department, Hospital Clínico San Carlos, Madrid 28040, SpainCardiovascular Research Unit, Cardiology Department, Hospital Clínico San Carlos, Madrid 28040, SpainCardiovascular Research Unit, Cardiology Department, Hospital Clínico San Carlos, Madrid 28040, SpainCardiovascular Research Unit, Cardiology Department, Hospital Clínico San Carlos, Madrid 28040, SpainCardiovascular Research Unit, Cardiology Department, Hospital Clínico San Carlos, Madrid 28040, SpainHypertension is a widely prevalent and important risk factor for cardiovascular diseases that increase with aging. The hallmark of hypertension in the elderly is increased vascular dysfunction. However, the molecular mechanisms by which increased blood pressure leads to vascular injury and impaired endothelial function are not well defined. In the present paper, we will analyze several mechanisms described in the scientific literature involved in hypertension in the elderly as endothelial dysfunction, increased oxygen delivery to tissues, inflammation, cellular apoptosis, and increased concentration of active metabolites. Also, we will focus on new molecular mechanisms involved in hypertension such as telomeres shortening, progenitor cells, circulating microparticles, and epigenetic factors that have appeared as possible causes of hypertension in the elderly. These molecular mechanisms may elucidate different origin for hypertension in the elderly and provide us with new targets for hypertension treatment.http://dx.doi.org/10.1155/2012/150107 |
| spellingShingle | Petra J. Mateos-Cáceres Jose J. Zamorano-León Pablo Rodríguez-Sierra Carlos Macaya Antonio J. López-Farré New and Old Mechanisms Associated with Hypertension in the Elderly International Journal of Hypertension |
| title | New and Old Mechanisms Associated with Hypertension in the Elderly |
| title_full | New and Old Mechanisms Associated with Hypertension in the Elderly |
| title_fullStr | New and Old Mechanisms Associated with Hypertension in the Elderly |
| title_full_unstemmed | New and Old Mechanisms Associated with Hypertension in the Elderly |
| title_short | New and Old Mechanisms Associated with Hypertension in the Elderly |
| title_sort | new and old mechanisms associated with hypertension in the elderly |
| url | http://dx.doi.org/10.1155/2012/150107 |
| work_keys_str_mv | AT petrajmateoscaceres newandoldmechanismsassociatedwithhypertensionintheelderly AT josejzamoranoleon newandoldmechanismsassociatedwithhypertensionintheelderly AT pablorodriguezsierra newandoldmechanismsassociatedwithhypertensionintheelderly AT carlosmacaya newandoldmechanismsassociatedwithhypertensionintheelderly AT antoniojlopezfarre newandoldmechanismsassociatedwithhypertensionintheelderly |