Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders
Helicobacter pylori (H. pylori) infection is one of the most common etiologies of gastrointestinal disorders. Considering the inadequacies and adverse impacts of antibiotic therapies, a potential treatment for H. pylori infection is the need of the hour. Hence, in this novel study, two probiotic Lac...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2458164 |
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| author | En-Su Chang Cheng-Yi Hsu Jui-Chen Li Rajni Dubey Wei-Chih Kan Ming-Jen Sheu Chia-Hui Cheng Chia-Yu Chang Chin-Chia Hsu Jiunn-Jye Chuu |
| author_facet | En-Su Chang Cheng-Yi Hsu Jui-Chen Li Rajni Dubey Wei-Chih Kan Ming-Jen Sheu Chia-Hui Cheng Chia-Yu Chang Chin-Chia Hsu Jiunn-Jye Chuu |
| author_sort | En-Su Chang |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) infection is one of the most common etiologies of gastrointestinal disorders. Considering the inadequacies and adverse impacts of antibiotic therapies, a potential treatment for H. pylori infection is the need of the hour. Hence, in this novel study, two probiotic Lactobacillus strains, Lactobacillus acidophilus (La) and Levilactobacillus brevis (Lb), were employed to ferment hot water extract of Talinum triangulare (TT) leaves to produce endogenous oligopolysaccharide prebiotics and several ginsenosides from TT fermentation broth (TTFB). Using 8%-TTFB, bacterial count, saponins yield (ginsenoside Re and chikusetsusaponin IVa) and DPPH radical scavenging potential of La and Lb were increased, while TNF-α and IL-1β were suppressed. Minimum inhibitory concentration values of H. pylori decreased to 4.2 mg/mL with increasing TTFB concentrations. Conclusively, probiotic Lactobacillus spp. fermented TT may prevent H. pylori associated gastrointestinal infections and related disorders through increasing bacterial count, anti-inflammatory, and anti-oxidative activities. |
| format | Article |
| id | doaj-art-8ab9c5c7a520408eb88ce4b4940981ec |
| institution | Kabale University |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-8ab9c5c7a520408eb88ce4b4940981ec2025-02-07T01:14:25ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452025-12-0123110.1080/19476337.2025.2458164Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disordersEn-Su Chang0Cheng-Yi Hsu1Jui-Chen Li2Rajni Dubey3Wei-Chih Kan4Ming-Jen Sheu5Chia-Hui Cheng6Chia-Yu Chang7Chin-Chia Hsu8Jiunn-Jye Chuu9Division of Gastroenterology, Department of Medicine, Wei-Gong Memorial Hospital, Miaoli, TaiwanDivision of Nephrology, Department of Medicine, Wei-Gong Memorial Hospital, Miaoli, TaiwanWei Gong Memorial Hospital, Miaoli, TaiwanDivision of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, TaiwanDivision of Nephrology, Chi Mei Medical Center, Tainan, TaiwanDivision of Gastroenterology and Hepatology, Chi Mei Medical Center, Tainan, TaiwanDepartment of Biotechnology and Food Technology, College of Smart Health, Southern Taiwan University of Science and Technology, Tainan, TaiwanDepartment of Neurology, Chi-Mei Medical Center, Tainan, TaiwanDepartment of Chinese Medicine, Chi-Mei Medical Center, Tainan, TaiwanWei Gong Memorial Hospital, Miaoli, TaiwanHelicobacter pylori (H. pylori) infection is one of the most common etiologies of gastrointestinal disorders. Considering the inadequacies and adverse impacts of antibiotic therapies, a potential treatment for H. pylori infection is the need of the hour. Hence, in this novel study, two probiotic Lactobacillus strains, Lactobacillus acidophilus (La) and Levilactobacillus brevis (Lb), were employed to ferment hot water extract of Talinum triangulare (TT) leaves to produce endogenous oligopolysaccharide prebiotics and several ginsenosides from TT fermentation broth (TTFB). Using 8%-TTFB, bacterial count, saponins yield (ginsenoside Re and chikusetsusaponin IVa) and DPPH radical scavenging potential of La and Lb were increased, while TNF-α and IL-1β were suppressed. Minimum inhibitory concentration values of H. pylori decreased to 4.2 mg/mL with increasing TTFB concentrations. Conclusively, probiotic Lactobacillus spp. fermented TT may prevent H. pylori associated gastrointestinal infections and related disorders through increasing bacterial count, anti-inflammatory, and anti-oxidative activities.https://www.tandfonline.com/doi/10.1080/19476337.2025.2458164Helicobacter pyloriLactobacillus acidophilusLevilactobacillus brevisfermentation brothprobioticTalinum triangulare |
| spellingShingle | En-Su Chang Cheng-Yi Hsu Jui-Chen Li Rajni Dubey Wei-Chih Kan Ming-Jen Sheu Chia-Hui Cheng Chia-Yu Chang Chin-Chia Hsu Jiunn-Jye Chuu Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders CyTA - Journal of Food Helicobacter pylori Lactobacillus acidophilus Levilactobacillus brevis fermentation broth probiotic Talinum triangulare |
| title | Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders |
| title_full | Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders |
| title_fullStr | Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders |
| title_full_unstemmed | Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders |
| title_short | Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders |
| title_sort | therapeutic potential of probiotic lactobacillus spp fermented talinum triangulare on helicobacter pylori associated gastrointestinal infectious disorders |
| topic | Helicobacter pylori Lactobacillus acidophilus Levilactobacillus brevis fermentation broth probiotic Talinum triangulare |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2025.2458164 |
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