Neurodevelopment of preterm infants with glucose and sodium abnormalities
Background: Blood glucose and serum sodium abnormalities in very low birth weight infants may cause increased morbidity and mortality, but data regarding the long-term outcomes are limited. This study aimed to investigate the association between the peak and nadir blood glucose and serum sodium leve...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957221001285 |
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| author | Hui-Ying Yang Cheng-Han Lee Hsiao-Neng Chen Lon-Yen Tsao Jia-Yuh Chen Yu-Jun Chang Chien-Chou Hsiao |
| author_facet | Hui-Ying Yang Cheng-Han Lee Hsiao-Neng Chen Lon-Yen Tsao Jia-Yuh Chen Yu-Jun Chang Chien-Chou Hsiao |
| author_sort | Hui-Ying Yang |
| collection | DOAJ |
| description | Background: Blood glucose and serum sodium abnormalities in very low birth weight infants may cause increased morbidity and mortality, but data regarding the long-term outcomes are limited. This study aimed to investigate the association between the peak and nadir blood glucose and serum sodium levels and neurodevelopmental outcomes in very low birth weight infants. Methods: A single-center retrospective medical record of 284 infants with birth weight<1500 g born between February 1, 2011 and January 31, 2015 was reviewed. We analyzed the correlation between peak and nadir blood glucose and serum sodium levels during hospitalization and Bayley Scales of Infant and Toddler Development, third edition at 6, 12, and 24 months of corrected age. Results: A total of 284 very low birth weight premature infants were eligible, and 223, 208, and 188 patients were assessed at 6, 12, and 24 months of corrected age, respectively. Multiple linear regression analysis with generalized estimating equations showed that the BSID-III cognitive scores were significantly lower in the peak serum sodium group when sodium was ≧150 mmol/L (95% confidence interval −11.681 to −0.822) than when sodium did not exceed 150 mmol/L. Conclusion: A peak serum sodium of ≧150 mmol/L is associated with poor cognitive outcomes in very low birth weight infants. Further studies are necessary to determine if this association is causal or an expression of disease severity. |
| format | Article |
| id | doaj-art-8ab37fe0e12c4e63871525bb7a560b2a |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-8ab37fe0e12c4e63871525bb7a560b2a2025-08-20T03:06:47ZengElsevierPediatrics and Neonatology1875-95722021-11-0162664765410.1016/j.pedneo.2021.06.008Neurodevelopment of preterm infants with glucose and sodium abnormalitiesHui-Ying Yang0Cheng-Han Lee1Hsiao-Neng Chen2Lon-Yen Tsao3Jia-Yuh Chen4Yu-Jun Chang5Chien-Chou Hsiao6Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, TaiwanEpidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua, TaiwanDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Corresponding author. Department of Pediatrics, Changhua Christian Children's Hospital, #135 Nanshiao Street, Changhua City, 500, Taiwan.Background: Blood glucose and serum sodium abnormalities in very low birth weight infants may cause increased morbidity and mortality, but data regarding the long-term outcomes are limited. This study aimed to investigate the association between the peak and nadir blood glucose and serum sodium levels and neurodevelopmental outcomes in very low birth weight infants. Methods: A single-center retrospective medical record of 284 infants with birth weight<1500 g born between February 1, 2011 and January 31, 2015 was reviewed. We analyzed the correlation between peak and nadir blood glucose and serum sodium levels during hospitalization and Bayley Scales of Infant and Toddler Development, third edition at 6, 12, and 24 months of corrected age. Results: A total of 284 very low birth weight premature infants were eligible, and 223, 208, and 188 patients were assessed at 6, 12, and 24 months of corrected age, respectively. Multiple linear regression analysis with generalized estimating equations showed that the BSID-III cognitive scores were significantly lower in the peak serum sodium group when sodium was ≧150 mmol/L (95% confidence interval −11.681 to −0.822) than when sodium did not exceed 150 mmol/L. Conclusion: A peak serum sodium of ≧150 mmol/L is associated with poor cognitive outcomes in very low birth weight infants. Further studies are necessary to determine if this association is causal or an expression of disease severity.http://www.sciencedirect.com/science/article/pii/S1875957221001285glucoseneurodevelopmental disorderspreterm infantssodiumvery low birth weight |
| spellingShingle | Hui-Ying Yang Cheng-Han Lee Hsiao-Neng Chen Lon-Yen Tsao Jia-Yuh Chen Yu-Jun Chang Chien-Chou Hsiao Neurodevelopment of preterm infants with glucose and sodium abnormalities Pediatrics and Neonatology glucose neurodevelopmental disorders preterm infants sodium very low birth weight |
| title | Neurodevelopment of preterm infants with glucose and sodium abnormalities |
| title_full | Neurodevelopment of preterm infants with glucose and sodium abnormalities |
| title_fullStr | Neurodevelopment of preterm infants with glucose and sodium abnormalities |
| title_full_unstemmed | Neurodevelopment of preterm infants with glucose and sodium abnormalities |
| title_short | Neurodevelopment of preterm infants with glucose and sodium abnormalities |
| title_sort | neurodevelopment of preterm infants with glucose and sodium abnormalities |
| topic | glucose neurodevelopmental disorders preterm infants sodium very low birth weight |
| url | http://www.sciencedirect.com/science/article/pii/S1875957221001285 |
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