Glypican 3 as target therapy to prevent cell migration and proliferation in rhabdomyosarcoma

Glypican 3 as target therapy to prevent cell migration and proliferation in rhabdomyosarcoma

Abstract Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma of mesenchymal origin with two main variants, the embryonal, less aggressive, and the alveolar RMS, more metastatic. The role of the extracellular matrix (ECM) in the growth and migration of RMS, as in other cancers, is becoming incr...

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Bibliographic Details
Main Authors: Maira Bacchiega, Stefania D’Agostino, Antonella Grigoletto, Elena Poli, Paolo Bonvini, Gianni Bisogno, Gianfranco Pasut, Michela Pozzobon
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Extracellular matrix
Glypican 3
Rhabdomyosarcoma
HA-hydrogel model
Online Access:https://doi.org/10.1038/s41598-025-03466-x
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