Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.

Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.

Transforming growth factor β (TGF-β) is a powerful promoter of cancer progression and a key target for antitumor therapy. As cancer cells exhibit active cholesterol metabolism, high density lipoproteins (HDLs) appear as an attractive delivery system for anticancer TGFβ-inhibitory molecules. We const...

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Bibliographic Details
Main Authors: José Medina-Echeverz, Jessica Fioravanti, Nancy Díaz-Valdés, Kathrin Frank, Fernando Aranda, Celia Gomar, Nuria Ardaiz, Javier Dotor, Viktor Umansky, Jesús Prieto, Pedro Berraondo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096799&type=printable
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