A Framework for the Objective Assessment of Registration Accuracy

Validation and accuracy assessment are the main bottlenecks preventing the adoption of image processing algorithms in the clinical practice. In the classical approach, a posteriori analysis is performed through objective metrics. In this work, a different approach based on Petri nets is proposed. Th...

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Main Authors: Francesca Pizzorni Ferrarese, Flavio Simonetti, Roberto Israel Foroni, Gloria Menegaz
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:International Journal of Biomedical Imaging
Online Access:http://dx.doi.org/10.1155/2014/128324
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author Francesca Pizzorni Ferrarese
Flavio Simonetti
Roberto Israel Foroni
Gloria Menegaz
author_facet Francesca Pizzorni Ferrarese
Flavio Simonetti
Roberto Israel Foroni
Gloria Menegaz
author_sort Francesca Pizzorni Ferrarese
collection DOAJ
description Validation and accuracy assessment are the main bottlenecks preventing the adoption of image processing algorithms in the clinical practice. In the classical approach, a posteriori analysis is performed through objective metrics. In this work, a different approach based on Petri nets is proposed. The basic idea consists in predicting the accuracy of a given pipeline based on the identification and characterization of the sources of inaccuracy. The concept is demonstrated on a case study: intrasubject rigid and affine registration of magnetic resonance images. Both synthetic and real data are considered. While synthetic data allow the benchmarking of the performance with respect to the ground truth, real data enable to assess the robustness of the methodology in real contexts as well as to determine the suitability of the use of synthetic data in the training phase. Results revealed a higher correlation and a lower dispersion among the metrics for simulated data, while the opposite trend was observed for pathologic ones. Results show that the proposed model not only provides a good prediction performance but also leads to the optimization of the end-to-end chain in terms of accuracy and robustness, setting the ground for its generalization to different and more complex scenarios.
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spelling doaj-art-8aae4bce713049c8b1671d41b55907832025-02-03T01:13:12ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962014-01-01201410.1155/2014/128324128324A Framework for the Objective Assessment of Registration AccuracyFrancesca Pizzorni Ferrarese0Flavio Simonetti1Roberto Israel Foroni2Gloria Menegaz3Department of Psychology, Royal Holloway, University of London, Egham TW20 0EX, UKDepartment of Computer Science, University of Verona, 37134 Verona, ItalyDepartment of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, 37126 Verona, ItalyDepartment of Computer Science, University of Verona, 37134 Verona, ItalyValidation and accuracy assessment are the main bottlenecks preventing the adoption of image processing algorithms in the clinical practice. In the classical approach, a posteriori analysis is performed through objective metrics. In this work, a different approach based on Petri nets is proposed. The basic idea consists in predicting the accuracy of a given pipeline based on the identification and characterization of the sources of inaccuracy. The concept is demonstrated on a case study: intrasubject rigid and affine registration of magnetic resonance images. Both synthetic and real data are considered. While synthetic data allow the benchmarking of the performance with respect to the ground truth, real data enable to assess the robustness of the methodology in real contexts as well as to determine the suitability of the use of synthetic data in the training phase. Results revealed a higher correlation and a lower dispersion among the metrics for simulated data, while the opposite trend was observed for pathologic ones. Results show that the proposed model not only provides a good prediction performance but also leads to the optimization of the end-to-end chain in terms of accuracy and robustness, setting the ground for its generalization to different and more complex scenarios.http://dx.doi.org/10.1155/2014/128324
spellingShingle Francesca Pizzorni Ferrarese
Flavio Simonetti
Roberto Israel Foroni
Gloria Menegaz
A Framework for the Objective Assessment of Registration Accuracy
International Journal of Biomedical Imaging
title A Framework for the Objective Assessment of Registration Accuracy
title_full A Framework for the Objective Assessment of Registration Accuracy
title_fullStr A Framework for the Objective Assessment of Registration Accuracy
title_full_unstemmed A Framework for the Objective Assessment of Registration Accuracy
title_short A Framework for the Objective Assessment of Registration Accuracy
title_sort framework for the objective assessment of registration accuracy
url http://dx.doi.org/10.1155/2014/128324
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