Chemical Composition, Acetylcholinesterase-Inhibitory Potential and Antioxidant Activity of Essential Oils from Three Populations of <i>Parthenium hysterophorus</i> L. in Ecuador
In this study, we analyzed the essential oils (EOs) extracted by steam distillation from the leaves and flowers of <i>Parthenium hysterophorus</i> L., grown in three different locations in southern Ecuador: Espíndola (ESP), Loja (LOJ) and Quilanga (QUI). Approximately 97.45%, 98.27% and...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/13/2712 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | In this study, we analyzed the essential oils (EOs) extracted by steam distillation from the leaves and flowers of <i>Parthenium hysterophorus</i> L., grown in three different locations in southern Ecuador: Espíndola (ESP), Loja (LOJ) and Quilanga (QUI). Approximately 97.45%, 98.27% and 95.99% of the oil constituents were identified using gas chromatography–mass spectrometry (GC-MS) and gas chromatography–flame ionization detection (GC-FID). Sesquiterpene hydrocarbons were predominant in the EOs. The most representative constituents of the sample from ESP were germacrene D (35.08%), myrcene (11.32%), (<i>E</i>)-β-ocimene (10.21%), (<i>E</i>)-caryophyllene (7.90%), germacra-4(15),5,10(14)-trien-1-α-ol (5.18%) and (<i>E</i>, <i>E</i>)-α-farnesene (4.99%), with an AChE IC<sub>50</sub> of 14.78 and with 16.38 and 93.16 µg/mL from ABTS and DPPH, respectively. The EOs from LOJ were characterized by the abundant presence of germacrene D (28.30%), myrcene (13.95%), (E)-β-ocimene (10.51%) and isolongifolan-7-α-ol (8.26%), with an AChE IC<sub>50</sub> of 16.65 and with 36.18 and 158.43 µg/mL from ABTS and DPPH, respectively. Finally, the EOs from QUI contained germacrene D (32.20%), myrcene (13.36%), (E)-β-ocimene (8.54%), (<i>E</i>, <i>E</i>)-α-farnesene (6.77%), germacra-4(15),5,10(14)-trien-1-α-ol (5.69%) and (E)-caryophyllene (5.37%), with an AChE IC<sub>50</sub> of 10.69 and with 14.50 and 92.98 µg/mL from ABTS and DPPH, respectively. This study identifies chemotypic variation in <i>P. hysterophorus</i> collected from different locations and, for the first time, the AChE inhibitor was evaluated. These findings provide a scientific basis for the clinical application of <i>P. hysterophorus</i> EOs in the future treatment of Alzheimer’s disease. |
|---|---|
| ISSN: | 1420-3049 |