Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens
Lysozymes, efficient alternative supplements to antibiotics, have several benefits in poultry production. In the present study, 120, one–day–old, Ross 308 broiler chickens of mixed sex, were allocated into 2 equal groups, lysozyme treated group (LTG) and lysozyme free group (LFG), to evaluate the ef...
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Taylor & Francis Group
2024-12-01
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| Series: | Animal Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10495398.2024.2309955 |
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| author | Mustafa Bastamy Ismail Raheel Ahmed Elbestawy Mohamed Diab Enas Hammad Lamiaa Elebeedy Amal M. El-Barbary Ghadeer M. Albadrani Mohamed M. Abdel-Daim Mervat A. Abdel-Latif Ahmed Orabi |
| author_facet | Mustafa Bastamy Ismail Raheel Ahmed Elbestawy Mohamed Diab Enas Hammad Lamiaa Elebeedy Amal M. El-Barbary Ghadeer M. Albadrani Mohamed M. Abdel-Daim Mervat A. Abdel-Latif Ahmed Orabi |
| author_sort | Mustafa Bastamy |
| collection | DOAJ |
| description | Lysozymes, efficient alternative supplements to antibiotics, have several benefits in poultry production. In the present study, 120, one–day–old, Ross 308 broiler chickens of mixed sex, were allocated into 2 equal groups, lysozyme treated group (LTG) and lysozyme free group (LFG), to evaluate the efficacy of lysozyme (Lysonir®) usage via both drinking water (thrice) and spray (once). LTG had better (p = 0.042) FCR, and higher European production efficiency factor compared to LFG (p = 0.042). The intestinal integrity score of LTG was decreased (p = 0.242) compared to that of LFG; 0.2 vs. 0.7. Higher (p ≤ 0.001) intestinal Lactobacillus counts were detected in chickens of LTG. Decreased (p ≤ 0.001) IL-1β and CXCL8 values were reported in LTG. The cellular immune modulation showed higher (p ≤ 0.001) opsonic activity (MΦ and phagocytic index) in LTG vs. LFG at 25 and 35 days. Also, higher (p ≤ 0.001) local, IgA, and humoral, HI titers, for both Newcastle, and avian influenza H5 viruses were found in LTG compared to LFG. In conclusion, microbial lysozyme could improve feed efficiency, intestinal integrity, Lactobacillus counts, anti-inflammatory, and immune responses in broiler chickens. |
| format | Article |
| id | doaj-art-8aa7cbb3a89b455aad1f2a6957c5dc85 |
| institution | DOAJ |
| issn | 1049-5398 1532-2378 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Biotechnology |
| spelling | doaj-art-8aa7cbb3a89b455aad1f2a6957c5dc852025-08-20T02:50:22ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2024.2309955Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickensMustafa Bastamy0Ismail Raheel1Ahmed Elbestawy2Mohamed Diab3Enas Hammad4Lamiaa Elebeedy5Amal M. El-Barbary6Ghadeer M. Albadrani7Mohamed M. Abdel-Daim8Mervat A. Abdel-Latif9Ahmed Orabi10Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptDepartment of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Beni-Suief University, Beni-Suief, EgyptDepartment of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Damanhour University, Elbeheira, EgyptDepartment of Animal Hygiene and Zoonoses, Faculty of Veterinary Medicine, New Valley University, El Kharga, EgyptAgricultural Research Center (ARC), Animal Health Research Institute-Mansoura Provincial Lab (AHRI-Mansoura), Dokki, Giza, EgyptFaculty of Pharmacy, New Valley University, El Kharga, EgyptPoultry Breeding Research Department, Animal Production Research Institute, Agriculture Research Center, Giza, EgyptDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi ArabiaDepartment of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Damanhour University, Damanhour, EgyptDepartment of Microbiology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptLysozymes, efficient alternative supplements to antibiotics, have several benefits in poultry production. In the present study, 120, one–day–old, Ross 308 broiler chickens of mixed sex, were allocated into 2 equal groups, lysozyme treated group (LTG) and lysozyme free group (LFG), to evaluate the efficacy of lysozyme (Lysonir®) usage via both drinking water (thrice) and spray (once). LTG had better (p = 0.042) FCR, and higher European production efficiency factor compared to LFG (p = 0.042). The intestinal integrity score of LTG was decreased (p = 0.242) compared to that of LFG; 0.2 vs. 0.7. Higher (p ≤ 0.001) intestinal Lactobacillus counts were detected in chickens of LTG. Decreased (p ≤ 0.001) IL-1β and CXCL8 values were reported in LTG. The cellular immune modulation showed higher (p ≤ 0.001) opsonic activity (MΦ and phagocytic index) in LTG vs. LFG at 25 and 35 days. Also, higher (p ≤ 0.001) local, IgA, and humoral, HI titers, for both Newcastle, and avian influenza H5 viruses were found in LTG compared to LFG. In conclusion, microbial lysozyme could improve feed efficiency, intestinal integrity, Lactobacillus counts, anti-inflammatory, and immune responses in broiler chickens.https://www.tandfonline.com/doi/10.1080/10495398.2024.2309955Lysozymepostbioticanti-inflammatoryimmunomodulationbroiler chickens |
| spellingShingle | Mustafa Bastamy Ismail Raheel Ahmed Elbestawy Mohamed Diab Enas Hammad Lamiaa Elebeedy Amal M. El-Barbary Ghadeer M. Albadrani Mohamed M. Abdel-Daim Mervat A. Abdel-Latif Ahmed Orabi Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens Animal Biotechnology Lysozyme postbiotic anti-inflammatory immunomodulation broiler chickens |
| title | Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| title_full | Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| title_fullStr | Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| title_full_unstemmed | Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| title_short | Postbiotic, anti-inflammatory, and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| title_sort | postbiotic anti inflammatory and immunomodulatory effects of aqueous microbial lysozyme in broiler chickens |
| topic | Lysozyme postbiotic anti-inflammatory immunomodulation broiler chickens |
| url | https://www.tandfonline.com/doi/10.1080/10495398.2024.2309955 |
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