Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study
Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024005039 |
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| author | Muqiu Zhang Xinyao Liu Xin Ran Runyan Gao Jitong Sun Kaiwen Zhuang Zimeng You Zhi Zhang Yuping Ran |
| author_facet | Muqiu Zhang Xinyao Liu Xin Ran Runyan Gao Jitong Sun Kaiwen Zhuang Zimeng You Zhi Zhang Yuping Ran |
| author_sort | Muqiu Zhang |
| collection | DOAJ |
| description | Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has showed effective antimicrobial activity. This study aimed to evaluate the antibacterial ability of hypocrellin mediated PDT against Cutibacterium acnes. Using modified broth dilution method and morphological observation, the antibacterial effect was tested under a series of experimental conditions. The results showed that hypocrellin initiates type II photodynamic reactions by inducing amount of reactive oxygen species, particularly singlet oxygen. Within a certain concentration range, hypocrellin effectively maintained the antibacterial efficacy with minimal damage to keratinocyte cells. These results provide new insights into the use of PDT for acne treatment. |
| format | Article |
| id | doaj-art-8aa5240ca72a4d8fa1fbca9f6a1a5e55 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-8aa5240ca72a4d8fa1fbca9f6a1a5e552025-02-01T04:11:48ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104467Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro studyMuqiu Zhang0Xinyao Liu1Xin Ran2Runyan Gao3Jitong Sun4Kaiwen Zhuang5Zimeng You6Zhi Zhang7Yuping Ran8Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Pathogen Research, West China Hospital, Sichuan University, Chengdu, China; Corresponding author at: Laboratory of Pathogen Research, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wuhou District, Chengdu, 610041, China.Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China; Corresponding author.Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has showed effective antimicrobial activity. This study aimed to evaluate the antibacterial ability of hypocrellin mediated PDT against Cutibacterium acnes. Using modified broth dilution method and morphological observation, the antibacterial effect was tested under a series of experimental conditions. The results showed that hypocrellin initiates type II photodynamic reactions by inducing amount of reactive oxygen species, particularly singlet oxygen. Within a certain concentration range, hypocrellin effectively maintained the antibacterial efficacy with minimal damage to keratinocyte cells. These results provide new insights into the use of PDT for acne treatment.http://www.sciencedirect.com/science/article/pii/S1572100024005039AntibacterialBiological productsPhotodynamic therapyPhotosensitizers |
| spellingShingle | Muqiu Zhang Xinyao Liu Xin Ran Runyan Gao Jitong Sun Kaiwen Zhuang Zimeng You Zhi Zhang Yuping Ran Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study Photodiagnosis and Photodynamic Therapy Antibacterial Biological products Photodynamic therapy Photosensitizers |
| title | Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study |
| title_full | Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study |
| title_fullStr | Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study |
| title_full_unstemmed | Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study |
| title_short | Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study |
| title_sort | hypocrellin a mediated photodynamic antibacterial activity against cutibacterium acnes an in vitro study |
| topic | Antibacterial Biological products Photodynamic therapy Photosensitizers |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024005039 |
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