Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation
Abstract Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three tra...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-52686-8 |
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| _version_ | 1850181504933560320 |
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| author | Liang Shen Zhenhua Tian Kaichun Yang Joseph Rich Jianping Xia Neil Upreti Jinxin Zhang Chuyi Chen Nanjing Hao Zhichao Pei Tony Jun Huang |
| author_facet | Liang Shen Zhenhua Tian Kaichun Yang Joseph Rich Jianping Xia Neil Upreti Jinxin Zhang Chuyi Chen Nanjing Hao Zhichao Pei Tony Jun Huang |
| author_sort | Liang Shen |
| collection | DOAJ |
| description | Abstract Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. Moreover, our tweezers can gradually increase the load on an acoustically trapped cell to achieve controllable cell deformation critical for characterizing cell mechanical properties. Furthermore, our platform allows for three-dimensional (3D) imaging of bioparticles without using complex confocal microscopy by rotating bioparticles with acoustic tweezers and taking images of each orientation using a standard microscope. With these capabilities, we anticipate the JSAT platform to play a pivotal role in various applications, including 3D imaging, tissue engineering, disease diagnostics, and drug testing. |
| format | Article |
| id | doaj-art-8aa1b21fde1a46119e604ea5498fdb12 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-8aa1b21fde1a46119e604ea5498fdb122025-08-20T02:17:53ZengNature PortfolioNature Communications2041-17232024-10-0115111110.1038/s41467-024-52686-8Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformationLiang Shen0Zhenhua Tian1Kaichun Yang2Joseph Rich3Jianping Xia4Neil Upreti5Jinxin Zhang6Chuyi Chen7Nanjing Hao8Zhichao Pei9Tony Jun Huang10Department of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering, Virginia Polytechnical Institute and State UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityDepartment of Mechanical Engineering and Materials Science, Duke UniversityAbstract Contactless microscale tweezers are highly effective tools for manipulating, patterning, and assembling bioparticles. However, current tweezers are limited in their ability to comprehensively manipulate bioparticles, providing only partial control over the six fundamental motions (three translational and three rotational motions). This study presents a joint subarray acoustic tweezers platform that leverages acoustic radiation force and viscous torque to control the six fundamental motions of single bioparticles. This breakthrough is significant as our manipulation mechanism allows for controlling the three translational and three rotational motions of single cells, as well as enabling complex manipulation that combines controlled translational and rotational motions. Moreover, our tweezers can gradually increase the load on an acoustically trapped cell to achieve controllable cell deformation critical for characterizing cell mechanical properties. Furthermore, our platform allows for three-dimensional (3D) imaging of bioparticles without using complex confocal microscopy by rotating bioparticles with acoustic tweezers and taking images of each orientation using a standard microscope. With these capabilities, we anticipate the JSAT platform to play a pivotal role in various applications, including 3D imaging, tissue engineering, disease diagnostics, and drug testing.https://doi.org/10.1038/s41467-024-52686-8 |
| spellingShingle | Liang Shen Zhenhua Tian Kaichun Yang Joseph Rich Jianping Xia Neil Upreti Jinxin Zhang Chuyi Chen Nanjing Hao Zhichao Pei Tony Jun Huang Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation Nature Communications |
| title | Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation |
| title_full | Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation |
| title_fullStr | Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation |
| title_full_unstemmed | Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation |
| title_short | Joint subarray acoustic tweezers enable controllable cell translation, rotation, and deformation |
| title_sort | joint subarray acoustic tweezers enable controllable cell translation rotation and deformation |
| url | https://doi.org/10.1038/s41467-024-52686-8 |
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