Organoids and organoid extracellular vesicles-based disease treatment strategies
Abstract Organoids are “mini-organs” that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. Extracellular vesicles (EVs) are nanoscale phospholipid bilayer vesicles secreted by living cells, rich in...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-02917-3 |
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| author | Guangyin Zhou Ruiyang Li Shihao Sheng Jingtao Huang Fengjin Zhou Yan Wei Han Liu Jiacan Su |
| author_facet | Guangyin Zhou Ruiyang Li Shihao Sheng Jingtao Huang Fengjin Zhou Yan Wei Han Liu Jiacan Su |
| author_sort | Guangyin Zhou |
| collection | DOAJ |
| description | Abstract Organoids are “mini-organs” that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. Extracellular vesicles (EVs) are nanoscale phospholipid bilayer vesicles secreted by living cells, rich in bioactive molecules, with excellent biocompatibility and low immunogenicity. Compared to EVs, organoid-derived EVs (OEVs) exhibit higher yield and enhanced biological functions. Organoids possess stem cell characteristics, and OEVs are capable of delivering active substances, making both highly promising for medical applications. In this review, we provide an overview of the fundamental biological principles of organoids and OEVs, and discuss their current applications in disease treatment. We then focus on the differences between OEVs and traditional EVs. Subsequently, we present methods for the engineering modification of OEVs. Finally, we critically summarize the advantages and challenges of organoids and OEVs. In conclusion, we believe that a deeper understanding of organoids and OEVs will provide innovative solutions to complex diseases. Graphical Abstract |
| format | Article |
| id | doaj-art-8a9ecc7cdbb6411e88bd23dede3294d1 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-8a9ecc7cdbb6411e88bd23dede3294d12024-11-10T12:41:31ZengBMCJournal of Nanobiotechnology1477-31552024-11-0122112110.1186/s12951-024-02917-3Organoids and organoid extracellular vesicles-based disease treatment strategiesGuangyin Zhou0Ruiyang Li1Shihao Sheng2Jingtao Huang3Fengjin Zhou4Yan Wei5Han Liu6Jiacan Su7Institute of Translational Medicine, Shanghai UniversityOrganoid Research Center, Shanghai UniversityDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Orthopedics, Shanghai Zhongye HospitalDepartment of Orthopaedics, Honghui Hospital, Xi’an Jiao Tong UniversityInstitute of Translational Medicine, Shanghai UniversityInstitute of Translational Medicine, Shanghai UniversityInstitute of Translational Medicine, Shanghai UniversityAbstract Organoids are “mini-organs” that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. Extracellular vesicles (EVs) are nanoscale phospholipid bilayer vesicles secreted by living cells, rich in bioactive molecules, with excellent biocompatibility and low immunogenicity. Compared to EVs, organoid-derived EVs (OEVs) exhibit higher yield and enhanced biological functions. Organoids possess stem cell characteristics, and OEVs are capable of delivering active substances, making both highly promising for medical applications. In this review, we provide an overview of the fundamental biological principles of organoids and OEVs, and discuss their current applications in disease treatment. We then focus on the differences between OEVs and traditional EVs. Subsequently, we present methods for the engineering modification of OEVs. Finally, we critically summarize the advantages and challenges of organoids and OEVs. In conclusion, we believe that a deeper understanding of organoids and OEVs will provide innovative solutions to complex diseases. Graphical Abstracthttps://doi.org/10.1186/s12951-024-02917-3OrganoidsExtracellular vesiclesOrganoids extracellular vesiclesEngineering modificationDisease treatment |
| spellingShingle | Guangyin Zhou Ruiyang Li Shihao Sheng Jingtao Huang Fengjin Zhou Yan Wei Han Liu Jiacan Su Organoids and organoid extracellular vesicles-based disease treatment strategies Journal of Nanobiotechnology Organoids Extracellular vesicles Organoids extracellular vesicles Engineering modification Disease treatment |
| title | Organoids and organoid extracellular vesicles-based disease treatment strategies |
| title_full | Organoids and organoid extracellular vesicles-based disease treatment strategies |
| title_fullStr | Organoids and organoid extracellular vesicles-based disease treatment strategies |
| title_full_unstemmed | Organoids and organoid extracellular vesicles-based disease treatment strategies |
| title_short | Organoids and organoid extracellular vesicles-based disease treatment strategies |
| title_sort | organoids and organoid extracellular vesicles based disease treatment strategies |
| topic | Organoids Extracellular vesicles Organoids extracellular vesicles Engineering modification Disease treatment |
| url | https://doi.org/10.1186/s12951-024-02917-3 |
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