Synthesis and Characterization of <i>N</i>-Nitroso-3-morpholinosydnonimine as NO Radical Donor
<i>N</i>-Nitroso-3-morpholinosydnonimine <b>3</b> was prepared by nitrosation of SIN-1 and characterized by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HRMS. Its structure, confirmed by single crystal X-ray diffraction analysis, was found to be in agree...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-09-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2024/4/M1886 |
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| Summary: | <i>N</i>-Nitroso-3-morpholinosydnonimine <b>3</b> was prepared by nitrosation of SIN-1 and characterized by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HRMS. Its structure, confirmed by single crystal X-ray diffraction analysis, was found to be in agreement with its mesoionic and aromatic character. Unlike 3-morpholino-sydnonimine (SIN-1), which releases both nitric oxide and superoxide radical, decomposition of this nitrosylated sydonimine could yield nitric oxide as the only decomposition product, and thus without the formation of toxic peroxynitrite. |
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| ISSN: | 1422-8599 |