Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis
The number of analogs being produced and substituted for bisphenol A (BPA), which belongs to the class of endocrine disruptors, is increasing day by day. The genotoxic effects of analogs such as bisphenol E (BPE), bisphenol Z (BPZ), and bisphenol A diglycidyl ether (BADGE)—containing almo...
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Academia.edu Journals
2024-06-01
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| author | Beyza Nalbantlar Özlem Çakal Arslan |
| author_facet | Beyza Nalbantlar Özlem Çakal Arslan |
| author_sort | Beyza Nalbantlar |
| collection | DOAJ |
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The number of analogs being produced and substituted for bisphenol A (BPA), which belongs to the class of endocrine disruptors, is increasing day by day. The genotoxic effects of analogs such as bisphenol E (BPE), bisphenol Z (BPZ), and bisphenol A diglycidyl ether (BADGE)—containing almost the entire alphabet—were investigated on the Mytilus galloprovincialis species exposed to increasing concentrations. When comparing their effects on gills, it was observed that BADGE and BPA had similar impacts, with the micronucleus (MN) frequency determined as BPA (32‰) > BADGE (26.5‰) > BPE = BPZ (24.6‰), respectively. Similarly, concerning hemolymph, the MN frequency was determined as BPA (31.2‰) > BPZ (28.6‰) > BPE (26.1‰) > BADGE (21.6‰), respectively. Nuclear bud formation in cells exposed to BPE is believed to affect the MN frequency. Comparing their impact on hepatopancreatic cells, the MN frequency was observed to be BPA (27.7‰) > BADGE (23.4‰) > BPZ (22.1‰) > BPE (21‰), respectively. All chemicals were noted to increase the MN frequency in hemolymph, gill, and hepatopancreas cells concerning the control and duration of exposure. Overall, all chemicals significantly increased MN frequency in hemolymph, gill, and hepatopancreas cells compared to controls, with variations based on the chemical and exposure duration. This research underscores the need for continued investigation into the genotoxic potential of BPA analogs for the safety and sustainability of aquatic ecosystems. |
| format | Article |
| id | doaj-art-8a9b8aaac0204838950097aa32c51993 |
| institution | Kabale University |
| issn | 2837-4010 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Academia.edu Journals |
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| spelling | doaj-art-8a9b8aaac0204838950097aa32c519932025-02-11T00:41:50ZengAcademia.edu JournalsAcademia Biology2837-40102024-06-012210.20935/AcadBiol6246Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysisBeyza Nalbantlar0Özlem Çakal Arslan1Department of Marine and Inland Water Science and Technology, Faculty of Fisheries, Ege University, Bornova 35100, Izmir, Turkey.Department of Marine and Inland Water Science and Technology, Faculty of Fisheries, Ege University, Bornova 35100, Izmir, Turkey. The number of analogs being produced and substituted for bisphenol A (BPA), which belongs to the class of endocrine disruptors, is increasing day by day. The genotoxic effects of analogs such as bisphenol E (BPE), bisphenol Z (BPZ), and bisphenol A diglycidyl ether (BADGE)—containing almost the entire alphabet—were investigated on the Mytilus galloprovincialis species exposed to increasing concentrations. When comparing their effects on gills, it was observed that BADGE and BPA had similar impacts, with the micronucleus (MN) frequency determined as BPA (32‰) > BADGE (26.5‰) > BPE = BPZ (24.6‰), respectively. Similarly, concerning hemolymph, the MN frequency was determined as BPA (31.2‰) > BPZ (28.6‰) > BPE (26.1‰) > BADGE (21.6‰), respectively. Nuclear bud formation in cells exposed to BPE is believed to affect the MN frequency. Comparing their impact on hepatopancreatic cells, the MN frequency was observed to be BPA (27.7‰) > BADGE (23.4‰) > BPZ (22.1‰) > BPE (21‰), respectively. All chemicals were noted to increase the MN frequency in hemolymph, gill, and hepatopancreas cells concerning the control and duration of exposure. Overall, all chemicals significantly increased MN frequency in hemolymph, gill, and hepatopancreas cells compared to controls, with variations based on the chemical and exposure duration. This research underscores the need for continued investigation into the genotoxic potential of BPA analogs for the safety and sustainability of aquatic ecosystems.https://www.academia.edu/121594481/Genotoxic_impact_of_BPA_and_analogs_BPE_BPZ_and_BADGE_on_Mytilus_galloprovincialis_insights_from_biomarker_analysis |
| spellingShingle | Beyza Nalbantlar Özlem Çakal Arslan Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis Academia Biology |
| title | Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis |
| title_full | Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis |
| title_fullStr | Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis |
| title_full_unstemmed | Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis |
| title_short | Genotoxic impact of BPA and analogs (BPE, BPZ, and BADGE) on Mytilus galloprovincialis: insights from biomarker analysis |
| title_sort | genotoxic impact of bpa and analogs bpe bpz and badge on mytilus galloprovincialis insights from biomarker analysis |
| url | https://www.academia.edu/121594481/Genotoxic_impact_of_BPA_and_analogs_BPE_BPZ_and_BADGE_on_Mytilus_galloprovincialis_insights_from_biomarker_analysis |
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