Statins: a tale of two pathways—cardiovascular savior, renal ineffectual
Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives. Managing dyslipidemia in CKD presents unique challenges requiring a c...
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| Format: | Article |
| Language: | English |
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Sungkyunkwan University School of Medi
2025-03-01
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| Series: | Precision and Future Medicine |
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| Online Access: | http://pfmjournal.org/upload/pdf/pfm-2025-00065.pdf |
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| _version_ | 1849735896459378688 |
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| author | Jihyun Yang |
| author_facet | Jihyun Yang |
| author_sort | Jihyun Yang |
| collection | DOAJ |
| description | Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives. Managing dyslipidemia in CKD presents unique challenges requiring a comprehensive understanding of alterations in lipid metabolism in renal dysfunction. This review explored the key factors influencing statin efficacy, safety, and guideline recommendations in the CKD population, with a focus on lipid-lowering strategies tailored to renal function. |
| format | Article |
| id | doaj-art-8a958b6d2ff84f1e9e87ef6a5889e2da |
| institution | DOAJ |
| issn | 2508-7940 2508-7959 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj-art-8a958b6d2ff84f1e9e87ef6a5889e2da2025-08-20T03:07:25ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592025-03-0191435210.23838/pfm.2025.00065184Statins: a tale of two pathways—cardiovascular savior, renal ineffectualJihyun Yang0 Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaStatins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives. Managing dyslipidemia in CKD presents unique challenges requiring a comprehensive understanding of alterations in lipid metabolism in renal dysfunction. This review explored the key factors influencing statin efficacy, safety, and guideline recommendations in the CKD population, with a focus on lipid-lowering strategies tailored to renal function.http://pfmjournal.org/upload/pdf/pfm-2025-00065.pdfhydroxymethylglutaryl-coa reductase inhibitorshydroxymethylglutaryl coa reductaseshyperlipidemiasrenal dialysisrenal insufficiency, chronic |
| spellingShingle | Jihyun Yang Statins: a tale of two pathways—cardiovascular savior, renal ineffectual Precision and Future Medicine hydroxymethylglutaryl-coa reductase inhibitors hydroxymethylglutaryl coa reductases hyperlipidemias renal dialysis renal insufficiency, chronic |
| title | Statins: a tale of two pathways—cardiovascular savior, renal ineffectual |
| title_full | Statins: a tale of two pathways—cardiovascular savior, renal ineffectual |
| title_fullStr | Statins: a tale of two pathways—cardiovascular savior, renal ineffectual |
| title_full_unstemmed | Statins: a tale of two pathways—cardiovascular savior, renal ineffectual |
| title_short | Statins: a tale of two pathways—cardiovascular savior, renal ineffectual |
| title_sort | statins a tale of two pathways cardiovascular savior renal ineffectual |
| topic | hydroxymethylglutaryl-coa reductase inhibitors hydroxymethylglutaryl coa reductases hyperlipidemias renal dialysis renal insufficiency, chronic |
| url | http://pfmjournal.org/upload/pdf/pfm-2025-00065.pdf |
| work_keys_str_mv | AT jihyunyang statinsataleoftwopathwayscardiovascularsaviorrenalineffectual |