Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies
Paracoccidioides spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (Dasypus novemcinctus), which...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5313691 |
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| author | Emma Camacho Gustavo A. Niño-Vega |
| author_facet | Emma Camacho Gustavo A. Niño-Vega |
| author_sort | Emma Camacho |
| collection | DOAJ |
| description | Paracoccidioides spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (Dasypus novemcinctus), which have been proposed as animal reservoir for these fungi. Human infection occurs by inhalation of conidia or mycelia fragments and is mostly associated with immunocompetent hosts inhabiting and/or working in endemic rural areas. In this review focusing on the pathogen perspective, we will discuss some of the microbial attributes and molecular mechanisms that enable Paracoccidioides spp. to tolerate, adapt, and ultimately avoid the host immune response, establishing infection. |
| format | Article |
| id | doaj-art-8a9226a911ac4cc1b822772e284d517e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8a9226a911ac4cc1b822772e284d517e2025-02-03T01:31:41ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/53136915313691Paracoccidioides Spp.: Virulence Factors and Immune-Evasion StrategiesEmma Camacho0Gustavo A. Niño-Vega1Department of Molecular Microbiology and Immunobiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USADepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, GTO, MexicoParacoccidioides spp. are dimorphic fungal pathogens responsible for one of the most relevant systemic mycoses in Latin America, paracoccidioidomycosis (PCM). Their exact ecological niche remains unknown; however, they have been isolated from soil samples and armadillos (Dasypus novemcinctus), which have been proposed as animal reservoir for these fungi. Human infection occurs by inhalation of conidia or mycelia fragments and is mostly associated with immunocompetent hosts inhabiting and/or working in endemic rural areas. In this review focusing on the pathogen perspective, we will discuss some of the microbial attributes and molecular mechanisms that enable Paracoccidioides spp. to tolerate, adapt, and ultimately avoid the host immune response, establishing infection.http://dx.doi.org/10.1155/2017/5313691 |
| spellingShingle | Emma Camacho Gustavo A. Niño-Vega Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies Mediators of Inflammation |
| title | Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies |
| title_full | Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies |
| title_fullStr | Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies |
| title_full_unstemmed | Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies |
| title_short | Paracoccidioides Spp.: Virulence Factors and Immune-Evasion Strategies |
| title_sort | paracoccidioides spp virulence factors and immune evasion strategies |
| url | http://dx.doi.org/10.1155/2017/5313691 |
| work_keys_str_mv | AT emmacamacho paracoccidioidessppvirulencefactorsandimmuneevasionstrategies AT gustavoaninovega paracoccidioidessppvirulencefactorsandimmuneevasionstrategies |