Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway

Abstract Background Ursodeoxycholic acid (UDCA), traditionally recognized for its hepatoprotective effects, has also shown potential in protecting kidney injury. This study aimed to evaluate the protective effects of UDCA against sepsis-induced acute kidney injury (AKI) and to elucidate the underlyi...

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Bibliographic Details
Main Authors: Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Nephrology
Subjects:
Ursodeoxycholic acid
Sepsis
Acute kidney injury
Lipopolysaccharides
NF-κB
Nrf2/HO-1
Online Access:https://doi.org/10.1186/s12882-025-03977-9
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