The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats
Diabetic ulcers usually occur in the lower extremities of diabetic patients. One in 20 diabetic patients will develop an ulcer, and 10% of those cases lead to amputation. This study aimed to investigate the effects of Javanese turmeric (Curcuma xanthorriza) extract on the number of fibroblasts, gra...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Kuwait Journal of Science |
| Online Access: | https://journalskuwait.org/kjs/index.php/KJS/article/view/15261 |
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| author | Heri Kristianto Husnul Khotimah Ryharti A. Sholeha Eky W. Mardianto Hasnah C. Sani Hardika A. Paratiwi |
| author_facet | Heri Kristianto Husnul Khotimah Ryharti A. Sholeha Eky W. Mardianto Hasnah C. Sani Hardika A. Paratiwi |
| author_sort | Heri Kristianto |
| collection | DOAJ |
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Diabetic ulcers usually occur in the lower extremities of diabetic patients. One in 20 diabetic patients will develop an ulcer, and 10% of those cases lead to amputation. This study aimed to investigate the effects of Javanese turmeric (Curcuma xanthorriza) extract on the number of fibroblasts, granulation, blood vessel and the rate of wound contraction in a Wistar rat model of the diabetic ulcer. This was an experimental study with post-test observations only and randomized control group design. Rats were divided into five groups: (1) negative control; (2) positive control; (3) P1; (4) P2; and (5) P3. Every rat was assessed for fibroblast number, granulation, blood vessel density, and wound contraction percentage. Javanese turmeric extract had a significant effect on histological parameters (fibroblast, blood vessels and tissue granulation) (p < 0.05) and wound contraction (p < 0.05). The double linear test revealed a significant relationship between fibroblasts, granulation, blood vessel quantity, and wound contraction (p < 0.05). Correlation and regression tests showed that Javanese turmeric extract explained 91% of the effects on fibroblasts, blood vessels, and granulation. Treatment with Javanese turmeric extract increased the number of fibroblasts, tissue granulation, blood vessel density and wound contraction in male diabetic wistar rats.
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| format | Article |
| id | doaj-art-8a8b745adc7346ff89cce269eb35b126 |
| institution | Kabale University |
| issn | 2307-4108 2307-4116 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kuwait Journal of Science |
| spelling | doaj-art-8a8b745adc7346ff89cce269eb35b1262025-08-20T03:24:56ZengElsevierKuwait Journal of Science2307-41082307-41162022-05-01501A10.48129/kjs.15261The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic ratsHeri Kristianto0Husnul Khotimah1Ryharti A. Sholeha2Eky W. Mardianto3Hasnah C. Sani4Hardika A. Paratiwi5School of Nursing, Faculty of Health Science, Brawijaya University, Malang, IndonesiaLaboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, IndonesiaPetrokimia Gresik Hospital, Gresik, IndonesiaPetrokimia Gresik Hospital, Gresik, IndonesiaLavalete Hospital, Malang, IndonesiaPersada Hospital, Malang, Indonesia Diabetic ulcers usually occur in the lower extremities of diabetic patients. One in 20 diabetic patients will develop an ulcer, and 10% of those cases lead to amputation. This study aimed to investigate the effects of Javanese turmeric (Curcuma xanthorriza) extract on the number of fibroblasts, granulation, blood vessel and the rate of wound contraction in a Wistar rat model of the diabetic ulcer. This was an experimental study with post-test observations only and randomized control group design. Rats were divided into five groups: (1) negative control; (2) positive control; (3) P1; (4) P2; and (5) P3. Every rat was assessed for fibroblast number, granulation, blood vessel density, and wound contraction percentage. Javanese turmeric extract had a significant effect on histological parameters (fibroblast, blood vessels and tissue granulation) (p < 0.05) and wound contraction (p < 0.05). The double linear test revealed a significant relationship between fibroblasts, granulation, blood vessel quantity, and wound contraction (p < 0.05). Correlation and regression tests showed that Javanese turmeric extract explained 91% of the effects on fibroblasts, blood vessels, and granulation. Treatment with Javanese turmeric extract increased the number of fibroblasts, tissue granulation, blood vessel density and wound contraction in male diabetic wistar rats. https://journalskuwait.org/kjs/index.php/KJS/article/view/15261 |
| spellingShingle | Heri Kristianto Husnul Khotimah Ryharti A. Sholeha Eky W. Mardianto Hasnah C. Sani Hardika A. Paratiwi The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats Kuwait Journal of Science |
| title | The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats |
| title_full | The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats |
| title_fullStr | The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats |
| title_full_unstemmed | The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats |
| title_short | The Effects of Javanese turmeric (Curcuma xanthorriza Roxb) on fibroblasts, granulation, blood vessel density, and contraction in wound healing of STZ-induced diabetic rats |
| title_sort | effects of javanese turmeric curcuma xanthorriza roxb on fibroblasts granulation blood vessel density and contraction in wound healing of stz induced diabetic rats |
| url | https://journalskuwait.org/kjs/index.php/KJS/article/view/15261 |
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