Cross-species RNAi therapy via AAV delivery alleviates neuropathic pain by targeting GCH1

Cross-species RNAi therapy via AAV delivery alleviates neuropathic pain by targeting GCH1

Tetrahydrobiopterin (BH4) expression is normally strictly controlled; however, its intracellular levels increase considerably following nerve damage. GTP cyclohydrolase I (GCH1) plays a crucial role in regulating BH4 concentration, with an upregulation observed in the dorsal root ganglion in cases o...

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Bibliographic Details
Main Authors: Heesue Chang, Kyoung Jin Lee, Minkyung Park, Ha-Na Woo, Ji Hyun Kim, Im Kyeung Kang, Hyochan Park, Chan Hee Chon, Heuiran Lee, Hyun Ho Jung
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Neuropathic pain
Adeno-associated virus
Tetrahydrobiopterin
GTP cyclohydrolase I
RNA interference
Multispecies-compatibility
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747924001983
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