Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy
<b>Background/Objectives:</b> T2 mapping is a quantitative magnetic resonance imaging (MRI) technique that provides information about tissue water content and molecular mobility. This study aimed to evaluate the diagnostic utility of T2 mapping in assessing sacroiliitis associated with s...
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2025-06-01
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| author | Mustafa Koyun Kemal Niyazi Arda |
| author_facet | Mustafa Koyun Kemal Niyazi Arda |
| author_sort | Mustafa Koyun |
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| description | <b>Background/Objectives:</b> T2 mapping is a quantitative magnetic resonance imaging (MRI) technique that provides information about tissue water content and molecular mobility. This study aimed to evaluate the diagnostic utility of T2 mapping in assessing sacroiliitis associated with spondyloarthropathy (SpA). <b>Methods:</b> A prospective study examined a total of 56 participants, comprising 31 SpA patients (<i>n</i> = 31) and 25 healthy controls (<i>n</i> = 25), who underwent sacroiliac joint MRI between August 2018 and August 2020. T2 mapping images were generated using multi-echo turbo spin echo (TSE) sequence, and quantitative T2 relaxation times were measured from bone and cartilage regions. Statistical analysis employed appropriate parametric and non-parametric tests with significance set at <i>p</i> < 0.05. <b>Results:</b> The mean T2 relaxation time measured from the areas with osteitis of SpA patients (100.23 ± 7.41 ms; 95% CI: 97.51–102.95) was significantly higher than that of the control group in normal bone (69.44 ± 4.37 ms; 95% CI: 67.64–71.24), and this difference was found to be statistically significant (<i>p</i> < 0.001). No significant difference was observed between cartilage T2 relaxation times in SpA patients and controls (<i>p</i> > 0.05). <b>Conclusions:</b> T2 mapping serves as a valuable quantitative imaging biomarker for diagnosing sacroiliitis associated with SpA, particularly by detecting bone marrow edema. The technique shows promise for objective disease assessment, though larger studies are needed to establish standardized reference values for T2 relaxation times in osteitis to enhance diagnostic accuracy and facilitate treatment monitoring. |
| format | Article |
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| institution | OA Journals |
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| spelling | doaj-art-8a87edd3bf4c48ee9f8891b12fa0d0992025-08-20T02:35:51ZengMDPI AGDiagnostics2075-44182025-06-011513163410.3390/diagnostics15131634Diagnostic Value of T2 Mapping in Sacroiliitis Associated with SpondyloarthropathyMustafa Koyun0Kemal Niyazi Arda1Department of Radiology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara 06010, TürkiyeDepartment of Radiology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara 06010, Türkiye<b>Background/Objectives:</b> T2 mapping is a quantitative magnetic resonance imaging (MRI) technique that provides information about tissue water content and molecular mobility. This study aimed to evaluate the diagnostic utility of T2 mapping in assessing sacroiliitis associated with spondyloarthropathy (SpA). <b>Methods:</b> A prospective study examined a total of 56 participants, comprising 31 SpA patients (<i>n</i> = 31) and 25 healthy controls (<i>n</i> = 25), who underwent sacroiliac joint MRI between August 2018 and August 2020. T2 mapping images were generated using multi-echo turbo spin echo (TSE) sequence, and quantitative T2 relaxation times were measured from bone and cartilage regions. Statistical analysis employed appropriate parametric and non-parametric tests with significance set at <i>p</i> < 0.05. <b>Results:</b> The mean T2 relaxation time measured from the areas with osteitis of SpA patients (100.23 ± 7.41 ms; 95% CI: 97.51–102.95) was significantly higher than that of the control group in normal bone (69.44 ± 4.37 ms; 95% CI: 67.64–71.24), and this difference was found to be statistically significant (<i>p</i> < 0.001). No significant difference was observed between cartilage T2 relaxation times in SpA patients and controls (<i>p</i> > 0.05). <b>Conclusions:</b> T2 mapping serves as a valuable quantitative imaging biomarker for diagnosing sacroiliitis associated with SpA, particularly by detecting bone marrow edema. The technique shows promise for objective disease assessment, though larger studies are needed to establish standardized reference values for T2 relaxation times in osteitis to enhance diagnostic accuracy and facilitate treatment monitoring.https://www.mdpi.com/2075-4418/15/13/1634T2 mappingT2 relaxation timesacroiliac jointsacroiliitisosteitis |
| spellingShingle | Mustafa Koyun Kemal Niyazi Arda Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy Diagnostics T2 mapping T2 relaxation time sacroiliac joint sacroiliitis osteitis |
| title | Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy |
| title_full | Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy |
| title_fullStr | Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy |
| title_full_unstemmed | Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy |
| title_short | Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy |
| title_sort | diagnostic value of t2 mapping in sacroiliitis associated with spondyloarthropathy |
| topic | T2 mapping T2 relaxation time sacroiliac joint sacroiliitis osteitis |
| url | https://www.mdpi.com/2075-4418/15/13/1634 |
| work_keys_str_mv | AT mustafakoyun diagnosticvalueoft2mappinginsacroiliitisassociatedwithspondyloarthropathy AT kemalniyaziarda diagnosticvalueoft2mappinginsacroiliitisassociatedwithspondyloarthropathy |