Association between vascular endothelial growth factor and atrial fibrillation: a systematic review
Abstract Background Atrial fibrillation (AF) is the most prevalent form of sustained cardiac arrhythmia, with vascular endothelial growth factor (VEGF) increasingly recognized for its potential role in the pathogenesis of AF through mechanisms involving atrial remodeling, inflammation, and fibrosis....
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12872-024-04460-3 |
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| author | Nikhil Sharma Mahalaqua Nazli Khatib R. Roopashree Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Muhammed Shabil Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Afukonyo Shidoiku Daniel Renu Sah |
| author_facet | Nikhil Sharma Mahalaqua Nazli Khatib R. Roopashree Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Muhammed Shabil Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Afukonyo Shidoiku Daniel Renu Sah |
| author_sort | Nikhil Sharma |
| collection | DOAJ |
| description | Abstract Background Atrial fibrillation (AF) is the most prevalent form of sustained cardiac arrhythmia, with vascular endothelial growth factor (VEGF) increasingly recognized for its potential role in the pathogenesis of AF through mechanisms involving atrial remodeling, inflammation, and fibrosis. This systematic review aims to synthesize available evidence on the association between VEGF and AF, exploring the implications of VEGF as a biomarker and therapeutic target. Methods We conducted a comprehensive search across PubMed, Embase, and Web of Science until November 10 2024, selecting studies based on pre-defined criteria that involve adults with AF and measurements of VEGF levels. The selected studies included observational and experimental designs, excluding non-English and methodologically insufficient publications. Narrative synthesis was used for summarising the results. Results Eight studies met the inclusion criteria. The studies show a general trend of elevated VEGF levels in AF patients compared to controls, with significant heterogeneity in findings across studies. VEGF subtypes such as VEGF-A and VEGF-D demonstrated stronger associations with AF risk compared to VEGF-C. These variations point to the complex role of VEGF in AF, influencing factors like angiogenesis, endothelial function, and inflammatory responses. Conclusion VEGF is potentially a significant contributor to AF pathophysiology, with its levels reflecting disease activity. The variability observed across studies suggests a need for standardized measurement approaches and further investigation into VEGF subtypes. Future research should focus on longitudinal studies to better understand the causal relationships and the potential of VEGF as a therapeutic target and biomarker in AF management. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-8a8501fd251a44fb9f320b17ee764616 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-8a8501fd251a44fb9f320b17ee7646162025-08-20T02:40:39ZengBMCBMC Cardiovascular Disorders1471-22612025-01-0125111010.1186/s12872-024-04460-3Association between vascular endothelial growth factor and atrial fibrillation: a systematic reviewNikhil Sharma0Mahalaqua Nazli Khatib1R. Roopashree2Mandeep Kaur3Manish Srivastava4Amit Barwal5G. V. Siva Prasad6Pranchal Rajput7Rukshar Syed8Kamal Kundra9Vinamra Mittal10Muhammed Shabil11Amit Kumar12Pancham Cajla13Ganesh Bushi14Rachana Mehta15Zaid Khan16Prakasini Satapathy17Shilpa Gaidhane18Afukonyo Shidoiku Daniel19Renu Sah20Department of Pharmacy Practice, National Institute of Pharmaceutical Education and ResearchDivision of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher EducationDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University)Department of Allied Healthcare and Sciences, Vivekananda Global UniversityDepartment of Endocrinology, NIMS UniversityChandigarh Pharmacy College, Chandigarh Group of CollegeDepartment of Chemistry, Raghu Engineering CollegeSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal UniversityIES Institute of Pharmacy, IES UniversityNew Delhi Institute of Management, Tughlakabad Institutional AreaGraphic Era (Deemed to be University), Graphic Era Institute of Medical SciencesNoida Institute of Engineering and Technology (Pharmacy Institute)Centre of Research Impact and Outcome, Chitkara UniversityChitkara Centre for Research and Development, Chitkara UniversitySchool of Pharmaceutical Sciences, Lovely Professional UniversityClinical Microbiology, RDC, Manav Rachna International Institute of Research and StudiesCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha UniversityUniversity Center for Research and Development, Chandigarh UniversityOne Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher EducationGlobal Health and Infectious Diseases Control Institute, Nasarawa State UniversitySR Sanjeevani HospitalAbstract Background Atrial fibrillation (AF) is the most prevalent form of sustained cardiac arrhythmia, with vascular endothelial growth factor (VEGF) increasingly recognized for its potential role in the pathogenesis of AF through mechanisms involving atrial remodeling, inflammation, and fibrosis. This systematic review aims to synthesize available evidence on the association between VEGF and AF, exploring the implications of VEGF as a biomarker and therapeutic target. Methods We conducted a comprehensive search across PubMed, Embase, and Web of Science until November 10 2024, selecting studies based on pre-defined criteria that involve adults with AF and measurements of VEGF levels. The selected studies included observational and experimental designs, excluding non-English and methodologically insufficient publications. Narrative synthesis was used for summarising the results. Results Eight studies met the inclusion criteria. The studies show a general trend of elevated VEGF levels in AF patients compared to controls, with significant heterogeneity in findings across studies. VEGF subtypes such as VEGF-A and VEGF-D demonstrated stronger associations with AF risk compared to VEGF-C. These variations point to the complex role of VEGF in AF, influencing factors like angiogenesis, endothelial function, and inflammatory responses. Conclusion VEGF is potentially a significant contributor to AF pathophysiology, with its levels reflecting disease activity. The variability observed across studies suggests a need for standardized measurement approaches and further investigation into VEGF subtypes. Future research should focus on longitudinal studies to better understand the causal relationships and the potential of VEGF as a therapeutic target and biomarker in AF management. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-024-04460-3Atrial fibrillationVEGFSystematic reviewBiomarkersCardiac arrhythmiaAngiogenesis |
| spellingShingle | Nikhil Sharma Mahalaqua Nazli Khatib R. Roopashree Mandeep Kaur Manish Srivastava Amit Barwal G. V. Siva Prasad Pranchal Rajput Rukshar Syed Kamal Kundra Vinamra Mittal Muhammed Shabil Amit Kumar Pancham Cajla Ganesh Bushi Rachana Mehta Zaid Khan Prakasini Satapathy Shilpa Gaidhane Afukonyo Shidoiku Daniel Renu Sah Association between vascular endothelial growth factor and atrial fibrillation: a systematic review BMC Cardiovascular Disorders Atrial fibrillation VEGF Systematic review Biomarkers Cardiac arrhythmia Angiogenesis |
| title | Association between vascular endothelial growth factor and atrial fibrillation: a systematic review |
| title_full | Association between vascular endothelial growth factor and atrial fibrillation: a systematic review |
| title_fullStr | Association between vascular endothelial growth factor and atrial fibrillation: a systematic review |
| title_full_unstemmed | Association between vascular endothelial growth factor and atrial fibrillation: a systematic review |
| title_short | Association between vascular endothelial growth factor and atrial fibrillation: a systematic review |
| title_sort | association between vascular endothelial growth factor and atrial fibrillation a systematic review |
| topic | Atrial fibrillation VEGF Systematic review Biomarkers Cardiac arrhythmia Angiogenesis |
| url | https://doi.org/10.1186/s12872-024-04460-3 |
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