Unveiling the placental bacterial microbiota: implications for maternal and infant health
The human placenta is a unique organ that forms under specific physiological conditions and plays a crucial role in nutrient and metabolite exchange between the mother and fetus. Research on the placenta is important for understanding maternal-fetal diseases. Traditionally, the placenta was consider...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1544216/full |
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| author | Zhuojun Xie Zhongsheng Chen Yang Chai Wang Yao Guangyu Ma |
| author_facet | Zhuojun Xie Zhongsheng Chen Yang Chai Wang Yao Guangyu Ma |
| author_sort | Zhuojun Xie |
| collection | DOAJ |
| description | The human placenta is a unique organ that forms under specific physiological conditions and plays a crucial role in nutrient and metabolite exchange between the mother and fetus. Research on the placenta is important for understanding maternal-fetal diseases. Traditionally, the placenta was considered “sterile,” but advancements in detection techniques have revealed the presence of a low level of microorganisms. This discovery challenges the traditional notion that the uterine placenta is sterile. The revelation of this truth marks a significant breakthrough in medical research, prompting more researchers to focus on this vital organ, the placenta. Placental microbial communities may originate from the oral, vaginal, and intestinal microbiota of expectant mothers. These microorganisms may reach the maternal-fetal interface, collectively shaping the placental microbiota and contributing to the composition of normal placental microbial communities. Abnormal placental microbial communities may be associated with some pregnancy complications and fetal developmental issues such as preterm birth, gestational hypertension, fetal growth restriction, and gestational diabetes mellitus. Intervention strategies targeting microbial communities, which include modulation of placental microbiota composition or function, such as probiotics, may help prevent or treat complications related to abnormal placental microbiota during pregnancy. |
| format | Article |
| id | doaj-art-8a7bc656edfe4d62a6f1c9eba3f43c06 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-8a7bc656edfe4d62a6f1c9eba3f43c062025-08-20T02:56:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-03-011610.3389/fphys.2025.15442161544216Unveiling the placental bacterial microbiota: implications for maternal and infant healthZhuojun Xie0Zhongsheng Chen1Yang Chai2Wang Yao3Guangyu Ma4General Medicine Department, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, ChinaDepartment of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaThe human placenta is a unique organ that forms under specific physiological conditions and plays a crucial role in nutrient and metabolite exchange between the mother and fetus. Research on the placenta is important for understanding maternal-fetal diseases. Traditionally, the placenta was considered “sterile,” but advancements in detection techniques have revealed the presence of a low level of microorganisms. This discovery challenges the traditional notion that the uterine placenta is sterile. The revelation of this truth marks a significant breakthrough in medical research, prompting more researchers to focus on this vital organ, the placenta. Placental microbial communities may originate from the oral, vaginal, and intestinal microbiota of expectant mothers. These microorganisms may reach the maternal-fetal interface, collectively shaping the placental microbiota and contributing to the composition of normal placental microbial communities. Abnormal placental microbial communities may be associated with some pregnancy complications and fetal developmental issues such as preterm birth, gestational hypertension, fetal growth restriction, and gestational diabetes mellitus. Intervention strategies targeting microbial communities, which include modulation of placental microbiota composition or function, such as probiotics, may help prevent or treat complications related to abnormal placental microbiota during pregnancy.https://www.frontiersin.org/articles/10.3389/fphys.2025.1544216/fullinfant healthmaternal healthplacental microbiotapregnancy complicationssource of placental microbiota |
| spellingShingle | Zhuojun Xie Zhongsheng Chen Yang Chai Wang Yao Guangyu Ma Unveiling the placental bacterial microbiota: implications for maternal and infant health Frontiers in Physiology infant health maternal health placental microbiota pregnancy complications source of placental microbiota |
| title | Unveiling the placental bacterial microbiota: implications for maternal and infant health |
| title_full | Unveiling the placental bacterial microbiota: implications for maternal and infant health |
| title_fullStr | Unveiling the placental bacterial microbiota: implications for maternal and infant health |
| title_full_unstemmed | Unveiling the placental bacterial microbiota: implications for maternal and infant health |
| title_short | Unveiling the placental bacterial microbiota: implications for maternal and infant health |
| title_sort | unveiling the placental bacterial microbiota implications for maternal and infant health |
| topic | infant health maternal health placental microbiota pregnancy complications source of placental microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1544216/full |
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