Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia
Aim. To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR. Methods. A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was us...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/2901581 |
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| author | Maisarah Jalalonmuhali Ng Kok Peng Lim Soo Kun |
| author_facet | Maisarah Jalalonmuhali Ng Kok Peng Lim Soo Kun |
| author_sort | Maisarah Jalalonmuhali |
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| description | Aim. To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR. Methods. A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were calculated. Results. A total of 51 subjects were recruited with mean measured GFR 42.04 (17.70–111.10) ml/min/1.73 m2. Estimated GFR based on CGBSA, 4-MDRD, and CKD-EPI were 40.47 (16.52–115.52), 35.90 (14.00–98.00), and 37.24 (14.00–121.00), respectively. Higher accuracy was noted in 4-MDRD equations throughout all GFR groups except for subgroup of GFR ≥ 60 ml/min/1.73 m2 where CGBSA was better. Conclusions. The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR < 60 ml/min/1.73 m2 and both BMI subgroups. |
| format | Article |
| id | doaj-art-8a787e2a49724005966d751b5ee1debf |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-8a787e2a49724005966d751b5ee1debf2025-08-20T02:09:18ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/29015812901581Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in MalaysiaMaisarah Jalalonmuhali0Ng Kok Peng1Lim Soo Kun2University Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaUniversity Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaUniversity Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaAim. To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR. Methods. A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were calculated. Results. A total of 51 subjects were recruited with mean measured GFR 42.04 (17.70–111.10) ml/min/1.73 m2. Estimated GFR based on CGBSA, 4-MDRD, and CKD-EPI were 40.47 (16.52–115.52), 35.90 (14.00–98.00), and 37.24 (14.00–121.00), respectively. Higher accuracy was noted in 4-MDRD equations throughout all GFR groups except for subgroup of GFR ≥ 60 ml/min/1.73 m2 where CGBSA was better. Conclusions. The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR < 60 ml/min/1.73 m2 and both BMI subgroups.http://dx.doi.org/10.1155/2017/2901581 |
| spellingShingle | Maisarah Jalalonmuhali Ng Kok Peng Lim Soo Kun Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia International Journal of Nephrology |
| title | Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia |
| title_full | Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia |
| title_fullStr | Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia |
| title_full_unstemmed | Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia |
| title_short | Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia |
| title_sort | comparative performance of creatinine based estimated glomerular filtration rate equations in the malays a pilot study in tertiary hospital in malaysia |
| url | http://dx.doi.org/10.1155/2017/2901581 |
| work_keys_str_mv | AT maisarahjalalonmuhali comparativeperformanceofcreatininebasedestimatedglomerularfiltrationrateequationsinthemalaysapilotstudyintertiaryhospitalinmalaysia AT ngkokpeng comparativeperformanceofcreatininebasedestimatedglomerularfiltrationrateequationsinthemalaysapilotstudyintertiaryhospitalinmalaysia AT limsookun comparativeperformanceofcreatininebasedestimatedglomerularfiltrationrateequationsinthemalaysapilotstudyintertiaryhospitalinmalaysia |