Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent
The search for lead product with beneficial pharmacological properties has become a great challenge and costly. Extraction and synthetic modification of bioactive compounds from natural resources has gained great attention and is cost effective. In this study, kojic acid was produced from fungal fer...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/1245712 |
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| author | Carolynne Zie Wei Sie Zainab Ngaini Nurashikin Suhaili Eswaran Madiahlagan |
| author_facet | Carolynne Zie Wei Sie Zainab Ngaini Nurashikin Suhaili Eswaran Madiahlagan |
| author_sort | Carolynne Zie Wei Sie |
| collection | DOAJ |
| description | The search for lead product with beneficial pharmacological properties has become a great challenge and costly. Extraction and synthetic modification of bioactive compounds from natural resources has gained great attention and is cost effective. In this study, kojic acid was produced from fungal fermentation, using sago waste as substrate, and chemically incorporated with chalcones and azobenzene to form a series of kojic ester derivatives and evaluated for antibacterial activities. Kojic ester bearing halogenated chalcone demonstrated active inhibition against Staphylococcus aureus compared to that of standard ampicillin. The inhibition increased as the electronegativity of halogens decreased, while incorporation of azobenzene derivatives on kojic acid backbone demonstrated fair antibacterial activity against Escherichia coli with minimum inhibitory concentration (MIC) of 190–330 ppm. The presence of C=C and N=N reactive moieties in both chalcone and azo molecules contributed to the potential biological activities of the kojic acid ester. |
| format | Article |
| id | doaj-art-8a77948da9f74af0a00e2745a4325d6c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8a77948da9f74af0a00e2745a4325d6c2025-02-03T01:24:23ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/12457121245712Synthesis of Kojic Ester Derivatives as Potential Antibacterial AgentCarolynne Zie Wei Sie0Zainab Ngaini1Nurashikin Suhaili2Eswaran Madiahlagan3Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaFaculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaFaculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaFaculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, MalaysiaThe search for lead product with beneficial pharmacological properties has become a great challenge and costly. Extraction and synthetic modification of bioactive compounds from natural resources has gained great attention and is cost effective. In this study, kojic acid was produced from fungal fermentation, using sago waste as substrate, and chemically incorporated with chalcones and azobenzene to form a series of kojic ester derivatives and evaluated for antibacterial activities. Kojic ester bearing halogenated chalcone demonstrated active inhibition against Staphylococcus aureus compared to that of standard ampicillin. The inhibition increased as the electronegativity of halogens decreased, while incorporation of azobenzene derivatives on kojic acid backbone demonstrated fair antibacterial activity against Escherichia coli with minimum inhibitory concentration (MIC) of 190–330 ppm. The presence of C=C and N=N reactive moieties in both chalcone and azo molecules contributed to the potential biological activities of the kojic acid ester.http://dx.doi.org/10.1155/2018/1245712 |
| spellingShingle | Carolynne Zie Wei Sie Zainab Ngaini Nurashikin Suhaili Eswaran Madiahlagan Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent Journal of Chemistry |
| title | Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent |
| title_full | Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent |
| title_fullStr | Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent |
| title_full_unstemmed | Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent |
| title_short | Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent |
| title_sort | synthesis of kojic ester derivatives as potential antibacterial agent |
| url | http://dx.doi.org/10.1155/2018/1245712 |
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