Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study
ABSTRACT Background To evaluate the effect of plasma exchange (PE) on the prognosis of patients with hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF). Methods The basic information (gender, age, blood type), the frequency and dosage of PE, the changes of indicators before and afte...
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Wiley
2025-04-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70729 |
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| author | Lu Wang Lu Song Jie Yang |
| author_facet | Lu Wang Lu Song Jie Yang |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | ABSTRACT Background To evaluate the effect of plasma exchange (PE) on the prognosis of patients with hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF). Methods The basic information (gender, age, blood type), the frequency and dosage of PE, the changes of indicators before and after PE, the adverse reactions related to PE and the prognosis of patients with HBV‐ACLF who received PE in our hospital from April 2018 to December 2021 were retrospectively analyzed. Results 197 patients with HBV‐ACLF who underwent PE were included in the analysis. Multivariate analysis shows that blood ammonia, ALBI, bacterial infection rate, HBV‐DNA load, MELD score, etc., are independent risk factors affecting the efficacy of PE treatment in HBV‐ACLF patients before and after PE treatment. Conclusion There are many factors influencing the efficacy of plasma exchange in patients with HBV‐ACLF. Compared to other factors, high blood ammonia levels and high ALBI are the independent risk factors for poor short‐term efficacy of plasma exchange. |
| format | Article |
| id | doaj-art-8a7400db12be4db98a92c1e9e0cfdf4a |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-8a7400db12be4db98a92c1e9e0cfdf4a2025-08-20T03:11:58ZengWileyHealth Science Reports2398-88352025-04-0184n/an/a10.1002/hsr2.70729Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional StudyLu Wang0Lu Song1Jie Yang2Clinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu ChinaClinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu ChinaClinical Laboratory, The People's Hospital of Danyang Danyang Hospital Affiliated to Nantong University Danyang Jiangsu ChinaABSTRACT Background To evaluate the effect of plasma exchange (PE) on the prognosis of patients with hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF). Methods The basic information (gender, age, blood type), the frequency and dosage of PE, the changes of indicators before and after PE, the adverse reactions related to PE and the prognosis of patients with HBV‐ACLF who received PE in our hospital from April 2018 to December 2021 were retrospectively analyzed. Results 197 patients with HBV‐ACLF who underwent PE were included in the analysis. Multivariate analysis shows that blood ammonia, ALBI, bacterial infection rate, HBV‐DNA load, MELD score, etc., are independent risk factors affecting the efficacy of PE treatment in HBV‐ACLF patients before and after PE treatment. Conclusion There are many factors influencing the efficacy of plasma exchange in patients with HBV‐ACLF. Compared to other factors, high blood ammonia levels and high ALBI are the independent risk factors for poor short‐term efficacy of plasma exchange.https://doi.org/10.1002/hsr2.70729acute‐on‐chronic liver failurealbumin‐bilirubin scoreblood ammoniahepatitis B virusplasma exchange |
| spellingShingle | Lu Wang Lu Song Jie Yang Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study Health Science Reports acute‐on‐chronic liver failure albumin‐bilirubin score blood ammonia hepatitis B virus plasma exchange |
| title | Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study |
| title_full | Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study |
| title_fullStr | Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study |
| title_full_unstemmed | Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study |
| title_short | Effect of Plasma Exchange on Hepatitis B‐Related Acute‐On‐Chronic Liver Failure: A Cross‐Sectional Study |
| title_sort | effect of plasma exchange on hepatitis b related acute on chronic liver failure a cross sectional study |
| topic | acute‐on‐chronic liver failure albumin‐bilirubin score blood ammonia hepatitis B virus plasma exchange |
| url | https://doi.org/10.1002/hsr2.70729 |
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