Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity
Dear Editor, We present two cases of Capecitabine-induced Hand-Foot Syndrome (HFS), hyperpigmentation on the oral mucosa, and nails. Case 1 A 28-year-old female, previously diagnosed with stage 4 left-sided inflammatory breast cancer, along with metastases to the right breast and skeletal sites o...
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JCDR Research and Publications Private Limited
2025-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/20578/67013_CE[Ra1]_F(SS)_QC(KK_RDW_SHU)_PF1(RI_SHU_OM)_redo_PFA_NC(SHU)_PN(IS).pdf |
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| author | Suprit Malali Sourya Acharya |
| author_facet | Suprit Malali Sourya Acharya |
| author_sort | Suprit Malali |
| collection | DOAJ |
| description | Dear Editor,
We present two cases of Capecitabine-induced Hand-Foot Syndrome (HFS), hyperpigmentation on the oral mucosa, and nails.
Case 1
A 28-year-old female, previously diagnosed with stage 4 left-sided inflammatory breast cancer, along with metastases to the right breast and skeletal sites one year ago, as confirmed by trucut biopsy and Positron Emission Tomography scan (PET), presented to our clinic with complaints of fatigue and generalised weakness persisting for the last month. The patient does not report any co-morbidities. Further clinical assessment and investigation are warranted to address the current symptoms and determine the appropriate course of management for the underlying cancer and associated symptoms. She received four cycles of injectable capecitabine and cyclophosphamide and later was shifted to oral chemotherapy with the same drugs for the last six months. All routine investigations such as complete blood count, liver function test, kidney function test, coagulation profile, and random blood sugar were within normal limits. The chest X-ray was normal. The Electrocardiogram (ECG) was suggestive of normal sinus rhythm. Upon examination, vitals were normal, and hyperpigmented patches and macules with blackish to grey colour were seen in the oral mucosa, gingival mucosa, teeth, palmar and dorsal aspects of hands, and plantar and dorsal aspects of the foot [Table/Fig-1a-d,2a-d]. |
| format | Article |
| id | doaj-art-8a6c6ff37d134958ad3b7d0164bdcca0 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-8a6c6ff37d134958ad3b7d0164bdcca02025-02-06T11:37:07ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-02-011902010210.7860/JCDR/2025/67013.20578Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare EntitySuprit Malali0Sourya Acharya1Junior Resident, Department of Internal Medicine, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Medical Education and Research, Sawangi, Meghe, Wardha, Maharashtra, India.Professor, Department of General Medicine, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Medical Education and Research, Sawangi, Meghe, Wardha, Maharashtra, India.Dear Editor, We present two cases of Capecitabine-induced Hand-Foot Syndrome (HFS), hyperpigmentation on the oral mucosa, and nails. Case 1 A 28-year-old female, previously diagnosed with stage 4 left-sided inflammatory breast cancer, along with metastases to the right breast and skeletal sites one year ago, as confirmed by trucut biopsy and Positron Emission Tomography scan (PET), presented to our clinic with complaints of fatigue and generalised weakness persisting for the last month. The patient does not report any co-morbidities. Further clinical assessment and investigation are warranted to address the current symptoms and determine the appropriate course of management for the underlying cancer and associated symptoms. She received four cycles of injectable capecitabine and cyclophosphamide and later was shifted to oral chemotherapy with the same drugs for the last six months. All routine investigations such as complete blood count, liver function test, kidney function test, coagulation profile, and random blood sugar were within normal limits. The chest X-ray was normal. The Electrocardiogram (ECG) was suggestive of normal sinus rhythm. Upon examination, vitals were normal, and hyperpigmented patches and macules with blackish to grey colour were seen in the oral mucosa, gingival mucosa, teeth, palmar and dorsal aspects of hands, and plantar and dorsal aspects of the foot [Table/Fig-1a-d,2a-d].https://jcdr.net/articles/PDF/20578/67013_CE[Ra1]_F(SS)_QC(KK_RDW_SHU)_PF1(RI_SHU_OM)_redo_PFA_NC(SHU)_PN(IS).pdfadenocarcinomainflammatorypositron emission tomography |
| spellingShingle | Suprit Malali Sourya Acharya Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity Journal of Clinical and Diagnostic Research adenocarcinoma inflammatory positron emission tomography |
| title | Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity |
| title_full | Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity |
| title_fullStr | Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity |
| title_full_unstemmed | Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity |
| title_short | Capecitabine-induced Hand-foot Syndrome with Hyperpigmentation on Oral Mucosa and Nails: A Rare Entity |
| title_sort | capecitabine induced hand foot syndrome with hyperpigmentation on oral mucosa and nails a rare entity |
| topic | adenocarcinoma inflammatory positron emission tomography |
| url | https://jcdr.net/articles/PDF/20578/67013_CE[Ra1]_F(SS)_QC(KK_RDW_SHU)_PF1(RI_SHU_OM)_redo_PFA_NC(SHU)_PN(IS).pdf |
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