Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method

All eukaryotic cell surfaces are coated with various types of glycans, which are essential molecules in biological events. In this review, we summarize recent integrated glycomics studies using various biological samples. We introduce an improved sialic acid linkage-specific alkylamidation (SALSA) m...

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Main Authors: Masaki Kurogochi, Chiharu Suzuki, Hisatoshi Hanamatsu, Jun-ichi Furukawa
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:BBA Advances
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667160325000079
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author Masaki Kurogochi
Chiharu Suzuki
Hisatoshi Hanamatsu
Jun-ichi Furukawa
author_facet Masaki Kurogochi
Chiharu Suzuki
Hisatoshi Hanamatsu
Jun-ichi Furukawa
author_sort Masaki Kurogochi
collection DOAJ
description All eukaryotic cell surfaces are coated with various types of glycans, which are essential molecules in biological events. In this review, we summarize recent integrated glycomics studies using various biological samples. We introduce an improved sialic acid linkage-specific alkylamidation (SALSA) method for sialylated glycan analysis and an automated glycosphingolipid-glycan preparation system for large-scale glycomic analysis of human plasma/serum. Finally, we explain the importance of integrated glycomics of glycoconjugates through total glycomic analysis of human serum and mouse brain tissue, and discuss prospects for exploring glycans as effective biomarkers of biological phenomena.
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spelling doaj-art-8a66476b2a0f444ea6061dd47a0f25432025-08-20T03:04:38ZengElsevierBBA Advances2667-16032025-01-01710014410.1016/j.bbadva.2025.100144Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA methodMasaki Kurogochi0Chiharu Suzuki1Hisatoshi Hanamatsu2Jun-ichi Furukawa3Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan; Corresponding authors at: Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan.Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, JapanInstitute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, JapanInstitute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, 060-8638, Japan; Corresponding authors at: Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, 464-8601, Japan.All eukaryotic cell surfaces are coated with various types of glycans, which are essential molecules in biological events. In this review, we summarize recent integrated glycomics studies using various biological samples. We introduce an improved sialic acid linkage-specific alkylamidation (SALSA) method for sialylated glycan analysis and an automated glycosphingolipid-glycan preparation system for large-scale glycomic analysis of human plasma/serum. Finally, we explain the importance of integrated glycomics of glycoconjugates through total glycomic analysis of human serum and mouse brain tissue, and discuss prospects for exploring glycans as effective biomarkers of biological phenomena.http://www.sciencedirect.com/science/article/pii/S2667160325000079GlycomicsGlycoconjugateSialic acidMass spectrometryAutomation
spellingShingle Masaki Kurogochi
Chiharu Suzuki
Hisatoshi Hanamatsu
Jun-ichi Furukawa
Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
BBA Advances
Glycomics
Glycoconjugate
Sialic acid
Mass spectrometry
Automation
title Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
title_full Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
title_fullStr Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
title_full_unstemmed Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
title_short Advances in total glycomic analysis including sialylated sub-glycan isomers by SALSA method
title_sort advances in total glycomic analysis including sialylated sub glycan isomers by salsa method
topic Glycomics
Glycoconjugate
Sialic acid
Mass spectrometry
Automation
url http://www.sciencedirect.com/science/article/pii/S2667160325000079
work_keys_str_mv AT masakikurogochi advancesintotalglycomicanalysisincludingsialylatedsubglycanisomersbysalsamethod
AT chiharusuzuki advancesintotalglycomicanalysisincludingsialylatedsubglycanisomersbysalsamethod
AT hisatoshihanamatsu advancesintotalglycomicanalysisincludingsialylatedsubglycanisomersbysalsamethod
AT junichifurukawa advancesintotalglycomicanalysisincludingsialylatedsubglycanisomersbysalsamethod