Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease

Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease

Objective Janus kinase family members are essential for signaling by multiple cytokines, including many implicated in systemic lupus erythematosus (SLE) pathogenesis. To test whether inhibition of JAK1 signaling can be efficacious in SLE, we used a JAK1‐selective inhibitor (ABT‐317) and evaluated it...

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Main Authors: Rachel E. Twomey, Stuart J. Perper, Susan V. Westmoreland, Swetha Srinivasan, Suzanne L. Mathieu, Kristine E. Frank, Jozsef Karman, Andrew J. Long, William J. Housley, Stephen H. Clarke
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:ACR Open Rheumatology
Online Access:https://doi.org/10.1002/acr2.11745
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