CpG hypomethylation at proximal promoter and 5’UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer

CpG hypomethylation at proximal promoter and 5’UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer

Abstract MYD88 is an IL-6 primary response gene and, its upregulation of expression has been shown to be a poor prognostic factor in epithelial ovarian cancer (EOC). We investigated the effects of CpG methylation at the proximal promoter/5’UTR and IL-6/SP1/IRF1 signaling on upregulation of MYD88 and...

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Bibliographic Details
Main Authors: Junyang Li, Bingjie Mei, Yi Zhu, Jianmei Huang, Meiying Li, Dengfeng Wang, Jianming Huang, Guonan Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Epithelial ovarian cancer
Myeloid differentiation factor 88
Interleukin-6
Specificity protein 1
Interferon regulatory factor 1
CpG methylation
Online Access:https://doi.org/10.1038/s41598-024-81975-x
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