RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2
Colorectal cancer (CRC) remains a major cause of carcinoma‐related deaths worldwide. MicroRNA‐498 (miR‐498) modulates the development of a variety of biological events, including tumorigenesis. Nevertheless, it is unclear whether miR‐498 plays a role in CRC. This study was designed to elucidate the...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.12767 |
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| _version_ | 1850124041799598080 |
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| author | Tongsheng Wang Ling Ma Wenxia Li Lei Ding Hong Gao |
| author_facet | Tongsheng Wang Ling Ma Wenxia Li Lei Ding Hong Gao |
| author_sort | Tongsheng Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) remains a major cause of carcinoma‐related deaths worldwide. MicroRNA‐498 (miR‐498) modulates the development of a variety of biological events, including tumorigenesis. Nevertheless, it is unclear whether miR‐498 plays a role in CRC. This study was designed to elucidate the underlying mechanism and role of miR‐498 in modulation of the viability and invasiveness of CRC cells. We report that CRC tissues and cells exhibited decreased expression of miR‐498, and that overexpression of miR‐498 resulted in reduced proliferation of CRC cells, concomitant with increased apoptosis. Furthermore, bioinformatic prediction and dual‐luciferase reporter assay revealed that miR‐498 targeted the 3′‐UTR of Bcl‐2 for silencing. However, Bcl‐2 overexpression suppressed the proapoptosis of miR‐498 on CRC cells. In summary, we describe a possible role of miR‐498 in CRC, which may lead to the identification of new targets for treatment of this malignancy. |
| format | Article |
| id | doaj-art-8a6345d538c54045a9b6e4f25e4d6f1b |
| institution | OA Journals |
| issn | 2211-5463 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-8a6345d538c54045a9b6e4f25e4d6f1b2025-08-20T02:34:25ZengWileyFEBS Open Bio2211-54632020-01-0110116817510.1002/2211-5463.12767RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2Tongsheng Wang0Ling Ma1Wenxia Li2Lei Ding3Hong Gao4Department of Colorectal Tumor Surgery Beijing Shijitan Hospital Affiliated to Capital Medical University ChinaDepartment of Colorectal Tumor Surgery Beijing Shijitan Hospital Affiliated to Capital Medical University ChinaDepartment of Colorectal Tumor Surgery Beijing Shijitan Hospital Affiliated to Capital Medical University ChinaDepartment of Colorectal Tumor Surgery Beijing Shijitan Hospital Affiliated to Capital Medical University ChinaDepartment of Colorectal Tumor Surgery Beijing Shijitan Hospital Affiliated to Capital Medical University ChinaColorectal cancer (CRC) remains a major cause of carcinoma‐related deaths worldwide. MicroRNA‐498 (miR‐498) modulates the development of a variety of biological events, including tumorigenesis. Nevertheless, it is unclear whether miR‐498 plays a role in CRC. This study was designed to elucidate the underlying mechanism and role of miR‐498 in modulation of the viability and invasiveness of CRC cells. We report that CRC tissues and cells exhibited decreased expression of miR‐498, and that overexpression of miR‐498 resulted in reduced proliferation of CRC cells, concomitant with increased apoptosis. Furthermore, bioinformatic prediction and dual‐luciferase reporter assay revealed that miR‐498 targeted the 3′‐UTR of Bcl‐2 for silencing. However, Bcl‐2 overexpression suppressed the proapoptosis of miR‐498 on CRC cells. In summary, we describe a possible role of miR‐498 in CRC, which may lead to the identification of new targets for treatment of this malignancy.https://doi.org/10.1002/2211-5463.12767apoptosisBcl‐2colorectal cancermiR‐498 |
| spellingShingle | Tongsheng Wang Ling Ma Wenxia Li Lei Ding Hong Gao RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 FEBS Open Bio apoptosis Bcl‐2 colorectal cancer miR‐498 |
| title | RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 |
| title_full | RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 |
| title_fullStr | RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 |
| title_full_unstemmed | RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 |
| title_short | RETRACTED: MicroRNA‐498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl‐2 |
| title_sort | retracted microrna 498 reduces the proliferation and invasion of colorectal cancer cells via targeting bcl 2 |
| topic | apoptosis Bcl‐2 colorectal cancer miR‐498 |
| url | https://doi.org/10.1002/2211-5463.12767 |
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