Clinical and functional significance of determining biological age in women during the reproductive period
Introduction. Biological age (BA) reflects the characteristics of the morphological and physiological state of the human body at a specific period of its life.This concept is of particular importance in reproductive medicine, because actual age does not always correlate with the state of organs and...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2025-03-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/2344 |
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| author | E. V. Kudryavtseva D. A. Berezina V. V. Bazarny L. G. Polushina M. А. Kopenkin A. N. Troitskaya V. V. Kovalev |
| author_facet | E. V. Kudryavtseva D. A. Berezina V. V. Bazarny L. G. Polushina M. А. Kopenkin A. N. Troitskaya V. V. Kovalev |
| author_sort | E. V. Kudryavtseva |
| collection | DOAJ |
| description | Introduction. Biological age (BA) reflects the characteristics of the morphological and physiological state of the human body at a specific period of its life.This concept is of particular importance in reproductive medicine, because actual age does not always correlate with the state of organs and systems.Aim: to develop a method for calculating BA for women aged 20–45 years, considering their physiological state and reproductive function.Materials and Methods. A single-stage non-randomized cohort study was conducted. To create the BA calculation model, a study was conducted with 100 healthy women aged 20–45 years. Seventy-eight parameters were analyzed, including anamnesis data, anthropometric parameters, data of general blood test, biochemical blood test, instrumental studies, assessment of overall antioxidant status (ОAS), from which the most informative variables were selected. The model was developed using multiple linear regression.Results. The most informative indicators for calculating BA were: ОAS, static balance time (SBT), body mass index (BMI), and number of former pregnancies. The developed BA calculation formula demonstrated high accuracy, correlating with chronological age (correlation coefficient of 0.947).Conclusion. The proposed BA calculation method is specifically designed for women of reproductive age and shows high accuracy and correlation with chronological age. The inclusion of antioxidant protection parameters, functional state indicators, and reproductive history makes the method versatile and applicable not only in reproductive medicine but also in general medical practice, obstetrics, gynecology, and other fields. |
| format | Article |
| id | doaj-art-8a61e8e215eb49319ae371f0a1f018bd |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-8a61e8e215eb49319ae371f0a1f018bd2025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942025-03-01191263410.17749/2313-7347/ob.gyn.rep.2025.582947Clinical and functional significance of determining biological age in women during the reproductive periodE. V. Kudryavtseva0D. A. Berezina1V. V. Bazarny2L. G. Polushina3M. А. Kopenkin4A. N. Troitskaya5V. V. Kovalev6Ural State Medical University, Ministry of Health of the Russian Federation; Ural Institute of Public Health Management named after A.B. BlokhinUral State Medical University, Ministry of Health of the Russian FederationUral State Medical University, Ministry of Health of the Russian FederationUral State Medical University, Ministry of Health of the Russian FederationUral State Medical University, Ministry of Health of the Russian FederationUral State Medical University, Ministry of Health of the Russian FederationUral Institute of Public Health Management named after A.B. BlokhinIntroduction. Biological age (BA) reflects the characteristics of the morphological and physiological state of the human body at a specific period of its life.This concept is of particular importance in reproductive medicine, because actual age does not always correlate with the state of organs and systems.Aim: to develop a method for calculating BA for women aged 20–45 years, considering their physiological state and reproductive function.Materials and Methods. A single-stage non-randomized cohort study was conducted. To create the BA calculation model, a study was conducted with 100 healthy women aged 20–45 years. Seventy-eight parameters were analyzed, including anamnesis data, anthropometric parameters, data of general blood test, biochemical blood test, instrumental studies, assessment of overall antioxidant status (ОAS), from which the most informative variables were selected. The model was developed using multiple linear regression.Results. The most informative indicators for calculating BA were: ОAS, static balance time (SBT), body mass index (BMI), and number of former pregnancies. The developed BA calculation formula demonstrated high accuracy, correlating with chronological age (correlation coefficient of 0.947).Conclusion. The proposed BA calculation method is specifically designed for women of reproductive age and shows high accuracy and correlation with chronological age. The inclusion of antioxidant protection parameters, functional state indicators, and reproductive history makes the method versatile and applicable not only in reproductive medicine but also in general medical practice, obstetrics, gynecology, and other fields.https://www.gynecology.su/jour/article/view/2344biological agebareproductive ageoverall antioxidant statusoasmultiple linear regressionwomen's health |
| spellingShingle | E. V. Kudryavtseva D. A. Berezina V. V. Bazarny L. G. Polushina M. А. Kopenkin A. N. Troitskaya V. V. Kovalev Clinical and functional significance of determining biological age in women during the reproductive period Акушерство, гинекология и репродукция biological age ba reproductive age overall antioxidant status oas multiple linear regression women's health |
| title | Clinical and functional significance of determining biological age in women during the reproductive period |
| title_full | Clinical and functional significance of determining biological age in women during the reproductive period |
| title_fullStr | Clinical and functional significance of determining biological age in women during the reproductive period |
| title_full_unstemmed | Clinical and functional significance of determining biological age in women during the reproductive period |
| title_short | Clinical and functional significance of determining biological age in women during the reproductive period |
| title_sort | clinical and functional significance of determining biological age in women during the reproductive period |
| topic | biological age ba reproductive age overall antioxidant status oas multiple linear regression women's health |
| url | https://www.gynecology.su/jour/article/view/2344 |
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