Synthesis of S-aryl dithiocarbamates and its in-silico studies
Environmentally friendly facile synthesis of aryl dithiocarbamates via a one-pot procedure by the reaction between secondary amines and carbon disulphide produced dithiocarbamates, which underwent copper-assisted intermolecular CS cross-coupling with aryl Iodides are developed. Cu2O is employed as...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625002401 |
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| author | Krishnarao Jayaram Desai Murugesan Santhosh Padmanaban Akashvarunan Ponraj Abarna Boopathi Shagunthala Hariprasad Sundaram Ganesh Babu Annamalai Pratheepkumar |
| author_facet | Krishnarao Jayaram Desai Murugesan Santhosh Padmanaban Akashvarunan Ponraj Abarna Boopathi Shagunthala Hariprasad Sundaram Ganesh Babu Annamalai Pratheepkumar |
| author_sort | Krishnarao Jayaram Desai |
| collection | DOAJ |
| description | Environmentally friendly facile synthesis of aryl dithiocarbamates via a one-pot procedure by the reaction between secondary amines and carbon disulphide produced dithiocarbamates, which underwent copper-assisted intermolecular CS cross-coupling with aryl Iodides are developed. Cu2O is employed as a catalyst and water used as a green solvent, owing to their high reaction efficiency and benign reaction conditions in the context of green chemistry. We demonstrated detailed studies of possible intermediates, product diversification, and in-silico properties for some of the novel S-Aryl dithiocarbamates. Further, the compound 3cg possess good binding affinity towards alpha-amylase protein in comparison with Metformin. |
| format | Article |
| id | doaj-art-8a5a56672ab143cbb24811a6f98fded6 |
| institution | DOAJ |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-8a5a56672ab143cbb24811a6f98fded62025-08-20T03:10:42ZengElsevierResults in Chemistry2211-71562025-05-011510225710.1016/j.rechem.2025.102257Synthesis of S-aryl dithiocarbamates and its in-silico studiesKrishnarao Jayaram Desai0Murugesan Santhosh1Padmanaban Akashvarunan2Ponraj Abarna3Boopathi Shagunthala Hariprasad4Sundaram Ganesh Babu5Annamalai Pratheepkumar6Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaNano-Catalysis Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaNano-Catalysis Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, IndiaDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India; Corresponding author.Environmentally friendly facile synthesis of aryl dithiocarbamates via a one-pot procedure by the reaction between secondary amines and carbon disulphide produced dithiocarbamates, which underwent copper-assisted intermolecular CS cross-coupling with aryl Iodides are developed. Cu2O is employed as a catalyst and water used as a green solvent, owing to their high reaction efficiency and benign reaction conditions in the context of green chemistry. We demonstrated detailed studies of possible intermediates, product diversification, and in-silico properties for some of the novel S-Aryl dithiocarbamates. Further, the compound 3cg possess good binding affinity towards alpha-amylase protein in comparison with Metformin.http://www.sciencedirect.com/science/article/pii/S2211715625002401CS couplingGreen solventLate-stage functionalizationIn-silicoMolecular docking |
| spellingShingle | Krishnarao Jayaram Desai Murugesan Santhosh Padmanaban Akashvarunan Ponraj Abarna Boopathi Shagunthala Hariprasad Sundaram Ganesh Babu Annamalai Pratheepkumar Synthesis of S-aryl dithiocarbamates and its in-silico studies Results in Chemistry CS coupling Green solvent Late-stage functionalization In-silico Molecular docking |
| title | Synthesis of S-aryl dithiocarbamates and its in-silico studies |
| title_full | Synthesis of S-aryl dithiocarbamates and its in-silico studies |
| title_fullStr | Synthesis of S-aryl dithiocarbamates and its in-silico studies |
| title_full_unstemmed | Synthesis of S-aryl dithiocarbamates and its in-silico studies |
| title_short | Synthesis of S-aryl dithiocarbamates and its in-silico studies |
| title_sort | synthesis of s aryl dithiocarbamates and its in silico studies |
| topic | CS coupling Green solvent Late-stage functionalization In-silico Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625002401 |
| work_keys_str_mv | AT krishnaraojayaramdesai synthesisofsaryldithiocarbamatesanditsinsilicostudies AT murugesansanthosh synthesisofsaryldithiocarbamatesanditsinsilicostudies AT padmanabanakashvarunan synthesisofsaryldithiocarbamatesanditsinsilicostudies AT ponrajabarna synthesisofsaryldithiocarbamatesanditsinsilicostudies AT boopathishagunthalahariprasad synthesisofsaryldithiocarbamatesanditsinsilicostudies AT sundaramganeshbabu synthesisofsaryldithiocarbamatesanditsinsilicostudies AT annamalaipratheepkumar synthesisofsaryldithiocarbamatesanditsinsilicostudies |