PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats
The impact of fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist, on the risk of thrombolysis-induced hemorrhage during the acute phase of stroke in a rat model of stroke was studied. One-hour middle cerebral artery occlusion followed by thrombolysis with tissue plasmin...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/246329 |
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| author | Sophie Gautier Thavarak Ouk Maud Pétrault Olivier Pétrault Vincent Bérézowski Régis Bordet |
| author_facet | Sophie Gautier Thavarak Ouk Maud Pétrault Olivier Pétrault Vincent Bérézowski Régis Bordet |
| author_sort | Sophie Gautier |
| collection | DOAJ |
| description | The impact of fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist, on the risk of thrombolysis-induced hemorrhage during the acute phase of stroke in a rat model of stroke was studied. One-hour middle cerebral artery occlusion followed by thrombolysis with tissue plasminogen activator was made in rats receiving either fenofibrate or vehicle for 72 h after stroke. Evaluation of infarct, hemorrhage, middle cerebral artery vasoreactivity, and immunochemistry (CD11b for microglial activation, myeloperoxidase, and ICAM-1 for neutrophil infiltration) was performed. The PPAR-alpha agonist significantly reduced the risk of hemorrhage after thrombolysis in parallel with a decrease in the infarct volume and in the stroke-induced vascular endothelial dysfunction. These effects are concomitant with a reduction in microglial activation and neutrophil infiltration in infarct area. Our results strengthen the idea that using drugs such as fenofibrate, with pleiotropic properties due to PPAR-alpha agonism, may be of value to reduce thrombolysis-induced hemorrhage during acute stroke. |
| format | Article |
| id | doaj-art-8a59ee8437524526b834b56274b2aa67 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-8a59ee8437524526b834b56274b2aa672025-08-20T03:37:50ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/246329246329PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in RatsSophie Gautier0Thavarak Ouk1Maud Pétrault2Olivier Pétrault3Vincent Bérézowski4Régis Bordet5U1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceU1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceU1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceU1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceU1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceU1171, Departement de Pharmacologie Medicale, University Lille Nord de France, Faculté de Médecine, CHU Lille, 1 Place de Verdun, 59037 Lille Cedex, FranceThe impact of fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist, on the risk of thrombolysis-induced hemorrhage during the acute phase of stroke in a rat model of stroke was studied. One-hour middle cerebral artery occlusion followed by thrombolysis with tissue plasminogen activator was made in rats receiving either fenofibrate or vehicle for 72 h after stroke. Evaluation of infarct, hemorrhage, middle cerebral artery vasoreactivity, and immunochemistry (CD11b for microglial activation, myeloperoxidase, and ICAM-1 for neutrophil infiltration) was performed. The PPAR-alpha agonist significantly reduced the risk of hemorrhage after thrombolysis in parallel with a decrease in the infarct volume and in the stroke-induced vascular endothelial dysfunction. These effects are concomitant with a reduction in microglial activation and neutrophil infiltration in infarct area. Our results strengthen the idea that using drugs such as fenofibrate, with pleiotropic properties due to PPAR-alpha agonism, may be of value to reduce thrombolysis-induced hemorrhage during acute stroke.http://dx.doi.org/10.1155/2015/246329 |
| spellingShingle | Sophie Gautier Thavarak Ouk Maud Pétrault Olivier Pétrault Vincent Bérézowski Régis Bordet PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats PPAR Research |
| title | PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats |
| title_full | PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats |
| title_fullStr | PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats |
| title_full_unstemmed | PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats |
| title_short | PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats |
| title_sort | ppar alpha agonist used at the acute phase of experimental ischemic stroke reduces occurrence of thrombolysis induced hemorrhage in rats |
| url | http://dx.doi.org/10.1155/2015/246329 |
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