The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review
Nociplastic pain is the fourth category of pain defined in recent years. It is a pain arising from altered nociception, despite the lack of clear evidence of actual or threatened tissue damage that causes activation of peripheral nociceptors nor evidence for disease or lesion of the somatosensory sy...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-01-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1003178/1003178.pdf |
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| author | Mariateresa Giglio Alberto Corriero Angela Preziosa Giustino Varrassi Filomena Puntillo |
| author_facet | Mariateresa Giglio Alberto Corriero Angela Preziosa Giustino Varrassi Filomena Puntillo |
| author_sort | Mariateresa Giglio |
| collection | DOAJ |
| description | Nociplastic pain is the fourth category of pain defined in recent years. It is a pain arising from altered nociception, despite the lack of clear evidence of actual or threatened tissue damage that causes activation of peripheral nociceptors nor evidence for disease or lesion of the somatosensory system causing the pain. This type of pain is usually multifocal, more diffuse or intense than expected and it is usually associated with other central nervous system-derived symptoms, such as fatigue, sleep, memory, and mood problems. It can occur in isolation or as part of a mixed-pain state in combination with ongoing nociceptive or neuropathic pain. It is associated with increased social and sanitary costs due to the difficulty of adequately treating it. Its pathogenesis is still poorly understood, even if a mounting body of evidence suggests a pivotal role in inflammation and immunity, which may be triggered by an infection and/or a trauma. This narrative review aims to summarise the current knowledge about the interplay of the immune system and nociplastic pathways activation and amplification. The challenge for the future will be to identify the exact role of inflammation and immunity, the cause of this activation, and its link to other pathogenetic factors of nociplastic pain, such as diet or microbiota alteration, social and phycological factors, together with a genetic and epigenetic predisposition. |
| format | Article |
| id | doaj-art-8a5869dd54984613ac05b2130f05be5f |
| institution | Kabale University |
| issn | 2768-6655 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj-art-8a5869dd54984613ac05b2130f05be5f2025-01-14T07:15:11ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552025-01-015100317810.37349/ei.2025.1003178The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative reviewMariateresa Giglio0https://orcid.org/0000-0002-4901-0045Alberto Corriero1https://orcid.org/0000-0002-9760-9394Angela Preziosa2Giustino Varrassi3https://orcid.org/0000-0002-3822-2923Filomena Puntillo4https://orcid.org/0000-0001-7274-6467Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70125 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70125 Bari, ItalyAnaesthesia and Intensive Care Unit, Policlinico Hospital, 70125 Bari, ItalyFondazione Paolo Procacci, 00193 Roma, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70125 Bari, ItalyNociplastic pain is the fourth category of pain defined in recent years. It is a pain arising from altered nociception, despite the lack of clear evidence of actual or threatened tissue damage that causes activation of peripheral nociceptors nor evidence for disease or lesion of the somatosensory system causing the pain. This type of pain is usually multifocal, more diffuse or intense than expected and it is usually associated with other central nervous system-derived symptoms, such as fatigue, sleep, memory, and mood problems. It can occur in isolation or as part of a mixed-pain state in combination with ongoing nociceptive or neuropathic pain. It is associated with increased social and sanitary costs due to the difficulty of adequately treating it. Its pathogenesis is still poorly understood, even if a mounting body of evidence suggests a pivotal role in inflammation and immunity, which may be triggered by an infection and/or a trauma. This narrative review aims to summarise the current knowledge about the interplay of the immune system and nociplastic pathways activation and amplification. The challenge for the future will be to identify the exact role of inflammation and immunity, the cause of this activation, and its link to other pathogenetic factors of nociplastic pain, such as diet or microbiota alteration, social and phycological factors, together with a genetic and epigenetic predisposition.https://www.explorationpub.com/uploads/Article/A1003178/1003178.pdfnociplastic painfibromyalgiaimmunityinflammation |
| spellingShingle | Mariateresa Giglio Alberto Corriero Angela Preziosa Giustino Varrassi Filomena Puntillo The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review Exploration of Immunology nociplastic pain fibromyalgia immunity inflammation |
| title | The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review |
| title_full | The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review |
| title_fullStr | The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review |
| title_full_unstemmed | The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review |
| title_short | The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review |
| title_sort | putative role of immune inflammatory mechanisms in nociplastic pain pathways a narrative review |
| topic | nociplastic pain fibromyalgia immunity inflammation |
| url | https://www.explorationpub.com/uploads/Article/A1003178/1003178.pdf |
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