CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages

CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages

CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. Here, we showed the downregulations of both TLR2 mRNA and protein in m...

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Main Authors:	Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang, Huidong Shi, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin
Format:	Article
Language:	English
Published:	Wiley 2018-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2018/8736949
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