Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study

Aim: This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. Patient & methods: An observational cross-sectional study. Results: A lower titer of AIA IgG was observed in the d...

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Main Authors: Bismark N Mohammed, Emmanuel K Ofori, Christian N Adekena, Seth K Amponsah, Henry Asare-Anane, Seth D Amanquah, Mubarak Abdul-Rahman, Kwesi N Amissah-Arthur
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Future Science OA
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Online Access:https://www.tandfonline.com/doi/10.2144/fsoa-2024-0002
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author Bismark N Mohammed
Emmanuel K Ofori
Christian N Adekena
Seth K Amponsah
Henry Asare-Anane
Seth D Amanquah
Mubarak Abdul-Rahman
Kwesi N Amissah-Arthur
author_facet Bismark N Mohammed
Emmanuel K Ofori
Christian N Adekena
Seth K Amponsah
Henry Asare-Anane
Seth D Amanquah
Mubarak Abdul-Rahman
Kwesi N Amissah-Arthur
author_sort Bismark N Mohammed
collection DOAJ
description Aim: This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. Patient & methods: An observational cross-sectional study. Results: A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5–560), DM-only = 50 (5–500), versus control = 200 (7–565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. Conclusion: A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.
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institution Kabale University
issn 2056-5623
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publishDate 2024-12-01
publisher Taylor & Francis Group
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series Future Science OA
spelling doaj-art-8a4f51a1e52744e09a260492ff784eb32025-08-20T03:50:38ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2024-0002Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional studyBismark N Mohammed0Emmanuel K Ofori1Christian N Adekena2Seth K Amponsah3Henry Asare-Anane4Seth D Amanquah5Mubarak Abdul-Rahman6Kwesi N Amissah-Arthur7Department of Chemical Pathology, University of Ghana Medical School, Accra, GhanaDepartment of Chemical Pathology, University of Ghana Medical School, Accra, GhanaUniversity of Ghana Medical Center, Accra, GhanaDepartment of Medical Pharmacology, University of Ghana Medical School, Accra, GhanaDepartment of Chemical Pathology, University of Ghana Medical School, Accra, GhanaDepartment of Chemical Pathology, University of Ghana Medical School, Accra, GhanaDepartment of Pathology, University of Ghana Medical School, Accra, GhanaEye Unit, Department of Surgery, University of Ghana Medical School, Accra, GhanaAim: This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. Patient & methods: An observational cross-sectional study. Results: A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5–560), DM-only = 50 (5–500), versus control = 200 (7–565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. Conclusion: A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.https://www.tandfonline.com/doi/10.2144/fsoa-2024-0002autoantibodiesdiabetes mellitusglycemiainsulinretinopathy
spellingShingle Bismark N Mohammed
Emmanuel K Ofori
Christian N Adekena
Seth K Amponsah
Henry Asare-Anane
Seth D Amanquah
Mubarak Abdul-Rahman
Kwesi N Amissah-Arthur
Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
Future Science OA
autoantibodies
diabetes mellitus
glycemia
insulin
retinopathy
title Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
title_full Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
title_fullStr Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
title_full_unstemmed Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
title_short Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study
title_sort levels of anti insulin antibodies in diabetic retinopathy patients an observational cross sectional study
topic autoantibodies
diabetes mellitus
glycemia
insulin
retinopathy
url https://www.tandfonline.com/doi/10.2144/fsoa-2024-0002
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