Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease
ABSTRACT Background: Research links retinal changes to cognitive decline in Parkinson's disease (PD), paralleling findings in Alzheimer's, raising questions about specific cortical patterns of cognition‐related retinal abnormalities in PD. Objective: The study aimed to explore whether reti...
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| Format: | Article |
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Wiley
2025-05-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70509 |
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| author | Kerstin Schweyer Tobias Mantel Benjamin Knier Lilian Aly Jan S. Kirschke Tobias Meindl Bernhard Haslinger |
| author_facet | Kerstin Schweyer Tobias Mantel Benjamin Knier Lilian Aly Jan S. Kirschke Tobias Meindl Bernhard Haslinger |
| author_sort | Kerstin Schweyer |
| collection | DOAJ |
| description | ABSTRACT Background: Research links retinal changes to cognitive decline in Parkinson's disease (PD), paralleling findings in Alzheimer's, raising questions about specific cortical patterns of cognition‐related retinal abnormalities in PD. Objective: The study aimed to explore whether retinal thinning linked to cognitive decline could act as a potential biomarker for cerebral atrophy in PD. Methods: Twenty seven patients with PD underwent cognitive and neurological assessments, along with retinal imaging using OCT and cerebral imaging using structural MRI. After identifying abnormal retinal layers associated with cognitive dysfunction through partial correlation analyses controlling for age‐related effects, associations between these retinal layers and the parcellated cerebral gray matter were assessed using multiple comparison‐corrected partial correlation analyses adjusted for age and gender. Results: Significant positive correlations were found between cognitive impairment measured by MoCA and specific retinal layers (IPL, GCL, and RNFL). Of these, strong associations were observed between the IPL and GCL and cortical thickness in brain the temporal lobe and limbic cortex, with more detailed further analysis showing significant correlations particularly within the middle and posterior cingulate cortex in the limbic cortex and the middle and superior temporal gyrus in the temporal lobe. Conclusion: Correlations between retinal thinning, cognitive decline, and specific patterns of cortical atrophy in PD support a potential of retinal measurements as a biomarker for cognitive impairment linked to cerebral neurodegeneration. |
| format | Article |
| id | doaj-art-8a42681e00a74a22afad7b0a25bb4c51 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-8a42681e00a74a22afad7b0a25bb4c512025-08-20T03:48:26ZengWileyBrain and Behavior2162-32792025-05-01155n/an/a10.1002/brb3.70509Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's DiseaseKerstin Schweyer0Tobias Mantel1Benjamin Knier2Lilian Aly3Jan S. Kirschke4Tobias Meindl5Bernhard Haslinger6Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyDepartment of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health Technical University of Munich Munich GermanyABSTRACT Background: Research links retinal changes to cognitive decline in Parkinson's disease (PD), paralleling findings in Alzheimer's, raising questions about specific cortical patterns of cognition‐related retinal abnormalities in PD. Objective: The study aimed to explore whether retinal thinning linked to cognitive decline could act as a potential biomarker for cerebral atrophy in PD. Methods: Twenty seven patients with PD underwent cognitive and neurological assessments, along with retinal imaging using OCT and cerebral imaging using structural MRI. After identifying abnormal retinal layers associated with cognitive dysfunction through partial correlation analyses controlling for age‐related effects, associations between these retinal layers and the parcellated cerebral gray matter were assessed using multiple comparison‐corrected partial correlation analyses adjusted for age and gender. Results: Significant positive correlations were found between cognitive impairment measured by MoCA and specific retinal layers (IPL, GCL, and RNFL). Of these, strong associations were observed between the IPL and GCL and cortical thickness in brain the temporal lobe and limbic cortex, with more detailed further analysis showing significant correlations particularly within the middle and posterior cingulate cortex in the limbic cortex and the middle and superior temporal gyrus in the temporal lobe. Conclusion: Correlations between retinal thinning, cognitive decline, and specific patterns of cortical atrophy in PD support a potential of retinal measurements as a biomarker for cognitive impairment linked to cerebral neurodegeneration.https://doi.org/10.1002/brb3.70509atrophycognitioncognitive dysfunctiongray mattermagnetic resonance imagingParkinson disease |
| spellingShingle | Kerstin Schweyer Tobias Mantel Benjamin Knier Lilian Aly Jan S. Kirschke Tobias Meindl Bernhard Haslinger Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease Brain and Behavior atrophy cognition cognitive dysfunction gray matter magnetic resonance imaging Parkinson disease |
| title | Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease |
| title_full | Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease |
| title_fullStr | Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease |
| title_full_unstemmed | Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease |
| title_short | Cognition‐Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease |
| title_sort | cognition associated changes in retinal thickness relate to limbic and temporal cortical atrophy in parkinson s disease |
| topic | atrophy cognition cognitive dysfunction gray matter magnetic resonance imaging Parkinson disease |
| url | https://doi.org/10.1002/brb3.70509 |
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