Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis
Abstract Background Chronic kidney disease (CKD) is a common condition among people living with HIV worldwide, but it is more common in patients from Africa. Both opportunistic infections and chronic illnesses are responsible for a large proportion of people living with HIV in low-resource settings...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-11212-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238702246592512 |
|---|---|
| author | Bruktawit Eshetu Alemu Gedefie Zewudu Mulatie Ermiyas Alemayehu Melaku Ashagrie Belete Saba Gebremichael Tekele Daniel Gebretsadik Weldehanna Hussen Ebrahim Mihret Tilahun Habtu Debash Agumas Shibabew Ousman Mohammed |
| author_facet | Bruktawit Eshetu Alemu Gedefie Zewudu Mulatie Ermiyas Alemayehu Melaku Ashagrie Belete Saba Gebremichael Tekele Daniel Gebretsadik Weldehanna Hussen Ebrahim Mihret Tilahun Habtu Debash Agumas Shibabew Ousman Mohammed |
| author_sort | Bruktawit Eshetu |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD) is a common condition among people living with HIV worldwide, but it is more common in patients from Africa. Both opportunistic infections and chronic illnesses are responsible for a large proportion of people living with HIV in low-resource settings like Ethiopia, which are linked to higher rates of morbidity and mortality. Further, as CKD is acknowledged as a major global public health issue affecting productivity, health, and healthcare costs, the goal of this systematic review and meta-analysis was to ascertain the pooled prevalence of CKD among people living with HIV in Ethiopia. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis criteria were followed by us when we carried out a systematic review and meta-analysis. Electronic databases like PubMed, Google Scholar, African Journal Online, Science Direct, Embase, Research Gate, Scopus, and Web of Sciences were searched in order to find pertinent articles. Domain-based assessment was used to evaluate the listed studies' quality. Stata version 14.0 software was used to conduct the statistical analysis. We used the Cochran's Q test and I2 statistics to assess heterogeneity. Using Egger's test and a funnel plot analysis, publication bias was evaluated. Using a random effect model, the pooled prevalence was calculated. Sub-group and sensitivity studies were also carried out. Results This systematic review and meta-analysis included 12 articles from Ethiopia, and 3364 People living with HIV were included. The overall pooled prevalence of chronic kidney disease (CKD) among People living with HIV in Ethiopia was 18.10% (95% CI: 14.17–22.03). According to the CKD calculation, the pooled prevalence of CKD was 18.06 (95% CI: 10.62–25.49) by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and 18.38 (95% CI: 15.75–21.02) by using the Modification of Diet in Renal Diseases (MDRD) formula. Using random-effect model, the I2 test result showed high heterogeneity I2 = 89.7% and P < 0.001. Additionally, Egger’s test of publication bias P-value was 0.017. Conclusion People living with HIV had a high prevalence of CKD, according to this systematic review and meta-analysis. Consequently, frequent CKD diagnosis at baseline, antiretroviral therapy follow-up and screening improves the quality of life for People living with HIV. Systematic review registration: PROSPERO (2023: CRD42023431245). |
| format | Article |
| id | doaj-art-8a41f386eed04f408c907a503997cd8a |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-8a41f386eed04f408c907a503997cd8a2025-08-20T04:01:25ZengBMCBMC Infectious Diseases1471-23342025-07-0125111210.1186/s12879-025-11212-xPrevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysisBruktawit Eshetu0Alemu Gedefie1Zewudu Mulatie2Ermiyas Alemayehu3Melaku Ashagrie Belete4Saba Gebremichael Tekele5Daniel Gebretsadik Weldehanna6Hussen Ebrahim7Mihret Tilahun8Habtu Debash 9Agumas Shibabew10Ousman Mohammed11Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityAbstract Background Chronic kidney disease (CKD) is a common condition among people living with HIV worldwide, but it is more common in patients from Africa. Both opportunistic infections and chronic illnesses are responsible for a large proportion of people living with HIV in low-resource settings like Ethiopia, which are linked to higher rates of morbidity and mortality. Further, as CKD is acknowledged as a major global public health issue affecting productivity, health, and healthcare costs, the goal of this systematic review and meta-analysis was to ascertain the pooled prevalence of CKD among people living with HIV in Ethiopia. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis criteria were followed by us when we carried out a systematic review and meta-analysis. Electronic databases like PubMed, Google Scholar, African Journal Online, Science Direct, Embase, Research Gate, Scopus, and Web of Sciences were searched in order to find pertinent articles. Domain-based assessment was used to evaluate the listed studies' quality. Stata version 14.0 software was used to conduct the statistical analysis. We used the Cochran's Q test and I2 statistics to assess heterogeneity. Using Egger's test and a funnel plot analysis, publication bias was evaluated. Using a random effect model, the pooled prevalence was calculated. Sub-group and sensitivity studies were also carried out. Results This systematic review and meta-analysis included 12 articles from Ethiopia, and 3364 People living with HIV were included. The overall pooled prevalence of chronic kidney disease (CKD) among People living with HIV in Ethiopia was 18.10% (95% CI: 14.17–22.03). According to the CKD calculation, the pooled prevalence of CKD was 18.06 (95% CI: 10.62–25.49) by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and 18.38 (95% CI: 15.75–21.02) by using the Modification of Diet in Renal Diseases (MDRD) formula. Using random-effect model, the I2 test result showed high heterogeneity I2 = 89.7% and P < 0.001. Additionally, Egger’s test of publication bias P-value was 0.017. Conclusion People living with HIV had a high prevalence of CKD, according to this systematic review and meta-analysis. Consequently, frequent CKD diagnosis at baseline, antiretroviral therapy follow-up and screening improves the quality of life for People living with HIV. Systematic review registration: PROSPERO (2023: CRD42023431245).https://doi.org/10.1186/s12879-025-11212-xChronic kidney diseaseEthiopiaMeta-analysisPeople living with HIVPrevalenceSystematic review |
| spellingShingle | Bruktawit Eshetu Alemu Gedefie Zewudu Mulatie Ermiyas Alemayehu Melaku Ashagrie Belete Saba Gebremichael Tekele Daniel Gebretsadik Weldehanna Hussen Ebrahim Mihret Tilahun Habtu Debash Agumas Shibabew Ousman Mohammed Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis BMC Infectious Diseases Chronic kidney disease Ethiopia Meta-analysis People living with HIV Prevalence Systematic review |
| title | Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis |
| title_full | Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis |
| title_fullStr | Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis |
| title_short | Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis |
| title_sort | prevalence of chronic kidney diseases among people living with hiv in ethiopia a systematic review and meta analysis |
| topic | Chronic kidney disease Ethiopia Meta-analysis People living with HIV Prevalence Systematic review |
| url | https://doi.org/10.1186/s12879-025-11212-x |
| work_keys_str_mv | AT bruktawiteshetu prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT alemugedefie prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT zewudumulatie prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT ermiyasalemayehu prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT melakuashagriebelete prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT sabagebremichaeltekele prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT danielgebretsadikweldehanna prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT hussenebrahim prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT mihrettilahun prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT habtudebash prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT agumasshibabew prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis AT ousmanmohammed prevalenceofchronickidneydiseasesamongpeoplelivingwithhivinethiopiaasystematicreviewandmetaanalysis |