Walking versus running and GFR trajectory in healthy young adults.
<h4>Background</h4>The effect of physical activity on the primary prevention of chronic kidney disease (CKD) is unclear. We assessed walking and running as exercise behaviors and their associations with individual-level risk for kidney function decline.<h4>Methods</h4>We cond...
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| Format: | Article |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0323392 |
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| author | Ronit Calderon-Margalit Ruth Lev Bar-Or Arnon Afek Dorit Tzur Dana Levin Dror Ben-Ruby Ariel Furer Gilad Twig Karl Skorecki Asaf Vivante |
| author_facet | Ronit Calderon-Margalit Ruth Lev Bar-Or Arnon Afek Dorit Tzur Dana Levin Dror Ben-Ruby Ariel Furer Gilad Twig Karl Skorecki Asaf Vivante |
| author_sort | Ronit Calderon-Margalit |
| collection | DOAJ |
| description | <h4>Background</h4>The effect of physical activity on the primary prevention of chronic kidney disease (CKD) is unclear. We assessed walking and running as exercise behaviors and their associations with individual-level risk for kidney function decline.<h4>Methods</h4>We conducted a historical cohort study in which we followed 20,976 young adults. Participants were interviewed periodically about their lifestyle, and clinical parameters were assessed. The decline in estimated glomerular filtration rate (eGFR) over time was divided into quartiles. Using logistic regressions, we estimated the odds ratio (OR) for being in the slowest declining quartile by consistency of running or walking. We also used Cox proportional hazards models to estimate the associations of physical activity with future eGFR < 90 ml/min/1.73m2. All models were adjusted for age, sex, smoking status, family history of kidney diseases, BMI, blood-pressure, baseline eGFR and serum cholesterol.<h4>Results</h4>During 9.5 years of follow-up, the eGFR decreased by 0.97 ml/min/1.73m2 per year. Participants who reported in two consecutive questionnaires on walking as a leisure time activity had an OR of 1.21 (95% confidence interval: 1.03-1.41) to have slow eGFR decline compared to those who were physically inactive. Participants who predominantly reported on running as their physical activity were less likely to be slow eGFR decliners (OR:0.81, 95% CI:0.71-0.93). Similarly, consistent walking was associated with decreased risk for future eGFR < 90 ml/min/1.73m2 in contrast to consistent running which was associated with an increased risk for reduced eGFR. All associations showed dose dependent effects in terms of the number of weekly activity sessions.<h4>Conclusions</h4>Consistent walking, as opposed to consistent running, was associated with slower eGFR decline compared to inactive participants. These associations start already within the normal GFR range. |
| format | Article |
| id | doaj-art-8a3dfb1c303a4e50ac738423954cc4bc |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-8a3dfb1c303a4e50ac738423954cc4bc2025-08-20T03:25:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032339210.1371/journal.pone.0323392Walking versus running and GFR trajectory in healthy young adults.Ronit Calderon-MargalitRuth Lev Bar-OrArnon AfekDorit TzurDana LevinDror Ben-RubyAriel FurerGilad TwigKarl SkoreckiAsaf Vivante<h4>Background</h4>The effect of physical activity on the primary prevention of chronic kidney disease (CKD) is unclear. We assessed walking and running as exercise behaviors and their associations with individual-level risk for kidney function decline.<h4>Methods</h4>We conducted a historical cohort study in which we followed 20,976 young adults. Participants were interviewed periodically about their lifestyle, and clinical parameters were assessed. The decline in estimated glomerular filtration rate (eGFR) over time was divided into quartiles. Using logistic regressions, we estimated the odds ratio (OR) for being in the slowest declining quartile by consistency of running or walking. We also used Cox proportional hazards models to estimate the associations of physical activity with future eGFR < 90 ml/min/1.73m2. All models were adjusted for age, sex, smoking status, family history of kidney diseases, BMI, blood-pressure, baseline eGFR and serum cholesterol.<h4>Results</h4>During 9.5 years of follow-up, the eGFR decreased by 0.97 ml/min/1.73m2 per year. Participants who reported in two consecutive questionnaires on walking as a leisure time activity had an OR of 1.21 (95% confidence interval: 1.03-1.41) to have slow eGFR decline compared to those who were physically inactive. Participants who predominantly reported on running as their physical activity were less likely to be slow eGFR decliners (OR:0.81, 95% CI:0.71-0.93). Similarly, consistent walking was associated with decreased risk for future eGFR < 90 ml/min/1.73m2 in contrast to consistent running which was associated with an increased risk for reduced eGFR. All associations showed dose dependent effects in terms of the number of weekly activity sessions.<h4>Conclusions</h4>Consistent walking, as opposed to consistent running, was associated with slower eGFR decline compared to inactive participants. These associations start already within the normal GFR range.https://doi.org/10.1371/journal.pone.0323392 |
| spellingShingle | Ronit Calderon-Margalit Ruth Lev Bar-Or Arnon Afek Dorit Tzur Dana Levin Dror Ben-Ruby Ariel Furer Gilad Twig Karl Skorecki Asaf Vivante Walking versus running and GFR trajectory in healthy young adults. PLoS ONE |
| title | Walking versus running and GFR trajectory in healthy young adults. |
| title_full | Walking versus running and GFR trajectory in healthy young adults. |
| title_fullStr | Walking versus running and GFR trajectory in healthy young adults. |
| title_full_unstemmed | Walking versus running and GFR trajectory in healthy young adults. |
| title_short | Walking versus running and GFR trajectory in healthy young adults. |
| title_sort | walking versus running and gfr trajectory in healthy young adults |
| url | https://doi.org/10.1371/journal.pone.0323392 |
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