Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort
Abstract Despite extensive research on pediatric trigger thumb, nationwide data on patient characteristics, coexisting birth defects, and development remain limited. This cohort study, using Korean National Health Insurance data, analyzed 1.9 million births (2009–2012) followed to age 6. We identifi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-01423-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850133107389235200 |
|---|---|
| author | So Young Kim Hyun Il Lee Ha-Na Yoo Bo Eun Han Man Yong Han Soonchul Lee |
| author_facet | So Young Kim Hyun Il Lee Ha-Na Yoo Bo Eun Han Man Yong Han Soonchul Lee |
| author_sort | So Young Kim |
| collection | DOAJ |
| description | Abstract Despite extensive research on pediatric trigger thumb, nationwide data on patient characteristics, coexisting birth defects, and development remain limited. This cohort study, using Korean National Health Insurance data, analyzed 1.9 million births (2009–2012) followed to age 6. We identified 10,167 trigger thumb cases and matched them 1:10 by sex and birth year with controls. Baseline features, congenital malformations (International Classification of Disease-10, Q00-Q89), and development at ages 4–6 (Korean Developmental Screening Test) were compared. Conditional logistic regression assessed comorbidity risk, expressed as odds ratio (OR), while generalized estimating equations evaluated the association between trigger thumb and developmental outcomes. The trigger thumb group (average diagnosis age: 31.3 months, 46.6% male) had 32.6% of surgery rate at an average age of 43 months. Trigger thumb group had significantly higher rates of renal agenesis and other reduction defects of kidney (OR 2.95, 95% CI 1.63–5.37), cleft palate (OR 1.79, 95% CI 1.19–2.70), and circulatory system malformations (OR 1.65, 95% CI 1.10–2.49) compared to controls. However, assessment using the Korean Developmental Screening Test revealed no significant delays in development, including gross and fine motor skills. Pediatric trigger thumb is linked to increased congenital malformations but doesn’t seem to hinder development. Screening for coexisting conditions and reassuring parents about development are crucial. |
| format | Article |
| id | doaj-art-8a37352aa2f94015b16dd1543e94daba |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8a37352aa2f94015b16dd1543e94daba2025-08-20T02:32:04ZengNature PortfolioScientific Reports2045-23222025-05-011511810.1038/s41598-025-01423-2Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohortSo Young Kim0Hyun Il Lee1Ha-Na Yoo2Bo Eun Han3Man Yong Han4Soonchul Lee5Department of Anatomy and Cell Biology, Seoul National University College of MedicineDepartment of Orthopedic Surgery, Ilsan Paik Hospital, Inje UniversityDepartment of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Pediatrics, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Pediatrics, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of MedicineAbstract Despite extensive research on pediatric trigger thumb, nationwide data on patient characteristics, coexisting birth defects, and development remain limited. This cohort study, using Korean National Health Insurance data, analyzed 1.9 million births (2009–2012) followed to age 6. We identified 10,167 trigger thumb cases and matched them 1:10 by sex and birth year with controls. Baseline features, congenital malformations (International Classification of Disease-10, Q00-Q89), and development at ages 4–6 (Korean Developmental Screening Test) were compared. Conditional logistic regression assessed comorbidity risk, expressed as odds ratio (OR), while generalized estimating equations evaluated the association between trigger thumb and developmental outcomes. The trigger thumb group (average diagnosis age: 31.3 months, 46.6% male) had 32.6% of surgery rate at an average age of 43 months. Trigger thumb group had significantly higher rates of renal agenesis and other reduction defects of kidney (OR 2.95, 95% CI 1.63–5.37), cleft palate (OR 1.79, 95% CI 1.19–2.70), and circulatory system malformations (OR 1.65, 95% CI 1.10–2.49) compared to controls. However, assessment using the Korean Developmental Screening Test revealed no significant delays in development, including gross and fine motor skills. Pediatric trigger thumb is linked to increased congenital malformations but doesn’t seem to hinder development. Screening for coexisting conditions and reassuring parents about development are crucial.https://doi.org/10.1038/s41598-025-01423-2Trigger thumbBig dataCo-morbidityCongenitalDevelopmentPediatric |
| spellingShingle | So Young Kim Hyun Il Lee Ha-Na Yoo Bo Eun Han Man Yong Han Soonchul Lee Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort Scientific Reports Trigger thumb Big data Co-morbidity Congenital Development Pediatric |
| title | Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| title_full | Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| title_fullStr | Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| title_full_unstemmed | Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| title_short | Association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| title_sort | association of trigger thumb with congenital malformations and developmental milestones among children in a nationwide birth cohort |
| topic | Trigger thumb Big data Co-morbidity Congenital Development Pediatric |
| url | https://doi.org/10.1038/s41598-025-01423-2 |
| work_keys_str_mv | AT soyoungkim associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort AT hyunillee associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort AT hanayoo associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort AT boeunhan associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort AT manyonghan associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort AT soonchullee associationoftriggerthumbwithcongenitalmalformationsanddevelopmentalmilestonesamongchildreninanationwidebirthcohort |