Methionine as a Spacer between Poly Acrylic acid and Ampicillin
In this work a novel drug delivery system through modification of poly acrylic acid with Methionine as a spacer between the poly acrylic acid which was converted to its acyl chloride and reacted with Methionine as spacer unit which has been reacted with Ampicillin drug. In vitro drug release study h...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad, College of Science for Women
2015-09-01
|
| Series: | مجلة بغداد للعلوم |
| Subjects: | |
| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849251448755322880 |
|---|---|
| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | In this work a novel drug delivery system through modification of poly acrylic acid with Methionine as a spacer between the poly acrylic acid which was converted to its acyl chloride and reacted with Methionine as spacer unit which has been reacted with Ampicillin drug. In vitro drug release study had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. Due to many problems associated with drug release and, this modification could decrease the side effect of drug. The prepared prodrug polymer was characterized by spectra method [FTIR and 1H?NMR]. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit. |
| format | Article |
| id | doaj-art-8a34cfb8ddfc421283ed601432b1c22c |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-8a34cfb8ddfc421283ed601432b1c22c2025-08-20T03:56:58ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862015-09-0112310.21123/bsj.12.3.563-571Methionine as a Spacer between Poly Acrylic acid and AmpicillinBaghdad Science JournalIn this work a novel drug delivery system through modification of poly acrylic acid with Methionine as a spacer between the poly acrylic acid which was converted to its acyl chloride and reacted with Methionine as spacer unit which has been reacted with Ampicillin drug. In vitro drug release study had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. Due to many problems associated with drug release and, this modification could decrease the side effect of drug. The prepared prodrug polymer was characterized by spectra method [FTIR and 1H?NMR]. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2101 Poly acrylic acid, Methionine, Ampicillin |
| spellingShingle | Baghdad Science Journal Methionine as a Spacer between Poly Acrylic acid and Ampicillin مجلة بغداد للعلوم Poly acrylic acid, Methionine, Ampicillin |
| title | Methionine as a Spacer between Poly Acrylic acid and Ampicillin |
| title_full | Methionine as a Spacer between Poly Acrylic acid and Ampicillin |
| title_fullStr | Methionine as a Spacer between Poly Acrylic acid and Ampicillin |
| title_full_unstemmed | Methionine as a Spacer between Poly Acrylic acid and Ampicillin |
| title_short | Methionine as a Spacer between Poly Acrylic acid and Ampicillin |
| title_sort | methionine as a spacer between poly acrylic acid and ampicillin |
| topic | Poly acrylic acid, Methionine, Ampicillin |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2101 |
| work_keys_str_mv | AT baghdadsciencejournal methionineasaspacerbetweenpolyacrylicacidandampicillin |