Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation
Although the adverse health effects of nanoparticles have been proposed and are being clarified, their aggravating effects on pre-existing pathological conditions have not been fully investigated. In this review, we provide insights into the immunotoxicity of both airborne and engineered nanoparticl...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.44 |
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| _version_ | 1850212519896940544 |
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| author | Ken-Ichiro Inoue Hirohisa Takano |
| author_facet | Ken-Ichiro Inoue Hirohisa Takano |
| author_sort | Ken-Ichiro Inoue |
| collection | DOAJ |
| description | Although the adverse health effects of nanoparticles have been proposed and are being clarified, their aggravating effects on pre-existing pathological conditions have not been fully investigated. In this review, we provide insights into the immunotoxicity of both airborne and engineered nanoparticles as an exacerbating factor on hypersusceptible subjects, especially those with immune-mediated pulmonary inflammation, using our in vivo experimental model. First, we exhibit the effects of nanoparticles on pulmonary inflammation induced by bacterial endotoxin (lipopolysaccharide: LPS) as a disease model in innate immunity, and demonstrate that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate the lung inflammation. Second, we introduce the effects of nanoparticles on allergic pulmonary inflammation as a disease model in adaptive immunity, and show that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic inflammation, including adjuvant effects on Th2-milieu. Third, we show that very small nanoparticle exposure exacerbates emphysematous pulmonary inflammation, which is concomitant with enhanced lung expression of proinflammatory molecules (including those that are innate immunity related). Taken together, nanoparticle exposure may synergistically facilitate pathological pulmonary inflammation via both innate and adaptive immunological impairment. |
| format | Article |
| id | doaj-art-8a3271fc15b345f194cca852a093f6df |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8a3271fc15b345f194cca852a093f6df2025-08-20T02:09:18ZengWileyThe Scientific World Journal1537-744X2011-01-011138239010.1100/tsw.2011.44Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary InflammationKen-Ichiro Inoue0Hirohisa Takano1Department of Public Health and Molecular Toxicology, School of Pharmacy, Kitasato University, Tokyo, JapanEnvironmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, JapanAlthough the adverse health effects of nanoparticles have been proposed and are being clarified, their aggravating effects on pre-existing pathological conditions have not been fully investigated. In this review, we provide insights into the immunotoxicity of both airborne and engineered nanoparticles as an exacerbating factor on hypersusceptible subjects, especially those with immune-mediated pulmonary inflammation, using our in vivo experimental model. First, we exhibit the effects of nanoparticles on pulmonary inflammation induced by bacterial endotoxin (lipopolysaccharide: LPS) as a disease model in innate immunity, and demonstrate that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate the lung inflammation. Second, we introduce the effects of nanoparticles on allergic pulmonary inflammation as a disease model in adaptive immunity, and show that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic inflammation, including adjuvant effects on Th2-milieu. Third, we show that very small nanoparticle exposure exacerbates emphysematous pulmonary inflammation, which is concomitant with enhanced lung expression of proinflammatory molecules (including those that are innate immunity related). Taken together, nanoparticle exposure may synergistically facilitate pathological pulmonary inflammation via both innate and adaptive immunological impairment.http://dx.doi.org/10.1100/tsw.2011.44 |
| spellingShingle | Ken-Ichiro Inoue Hirohisa Takano Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation The Scientific World Journal |
| title | Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation |
| title_full | Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation |
| title_fullStr | Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation |
| title_full_unstemmed | Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation |
| title_short | Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation |
| title_sort | aggravating impact of nanoparticles on immune mediated pulmonary inflammation |
| url | http://dx.doi.org/10.1100/tsw.2011.44 |
| work_keys_str_mv | AT kenichiroinoue aggravatingimpactofnanoparticlesonimmunemediatedpulmonaryinflammation AT hirohisatakano aggravatingimpactofnanoparticlesonimmunemediatedpulmonaryinflammation |