The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction
Myocardial infarction (MI) is a devastating disease with high morbidity and mortality caused by the irreversible loss of functional cardiomyocytes and heart failure (HF) due to the restricted blood supply. Mesenchymal stem cells (MSCs) have been emerging as lead candidates to treat MI and subsequent...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/5579904 |
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| author | Xianyun Wang Yida Tang Zhao Liu Yajuan Yin Quanhai Li Gang Liu Baoyong Yan |
| author_facet | Xianyun Wang Yida Tang Zhao Liu Yajuan Yin Quanhai Li Gang Liu Baoyong Yan |
| author_sort | Xianyun Wang |
| collection | DOAJ |
| description | Myocardial infarction (MI) is a devastating disease with high morbidity and mortality caused by the irreversible loss of functional cardiomyocytes and heart failure (HF) due to the restricted blood supply. Mesenchymal stem cells (MSCs) have been emerging as lead candidates to treat MI and subsequent HF mainly through secreting multitudinous factors of which exosomes act as the most effective constituent to boost the repair of heart function through carrying noncoding RNAs and proteins. Given the advantages of higher stability in the circulation, lower toxicity, and controllable transplantation dosage, exosomes have been described as a wonderful and promising cell-free treatment method in cardiovascular disease. Nowadays, MSC-derived exosomes have been proposed as a promising therapeutic approach to improve cardiac function and reverse heart remodeling. However, exosomes’ lack of modification cannot result in desired therapeutic effect. Hence, optimized exosomes can be developed via various engineering methods such as pharmacological compound preconditioned MSCs, genetically modified MSCs, or miRNA-loaded exosomes and peptide tagged exosomes to improve the targeting and therapeutic effects of exosomes. The biological characteristics, therapeutic potential, and optimizing strategy of exosomes will be described in our review. |
| format | Article |
| id | doaj-art-8a31c77d5a5a432bb8339ccc4846a3fa |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8a31c77d5a5a432bb8339ccc4846a3fa2025-08-20T02:09:18ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/55799045579904The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial InfarctionXianyun Wang0Yida Tang1Zhao Liu2Yajuan Yin3Quanhai Li4Gang Liu5Baoyong Yan6Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, Peking University Third Hospital, Beijing, ChinaTraditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaCell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaCell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaMyocardial infarction (MI) is a devastating disease with high morbidity and mortality caused by the irreversible loss of functional cardiomyocytes and heart failure (HF) due to the restricted blood supply. Mesenchymal stem cells (MSCs) have been emerging as lead candidates to treat MI and subsequent HF mainly through secreting multitudinous factors of which exosomes act as the most effective constituent to boost the repair of heart function through carrying noncoding RNAs and proteins. Given the advantages of higher stability in the circulation, lower toxicity, and controllable transplantation dosage, exosomes have been described as a wonderful and promising cell-free treatment method in cardiovascular disease. Nowadays, MSC-derived exosomes have been proposed as a promising therapeutic approach to improve cardiac function and reverse heart remodeling. However, exosomes’ lack of modification cannot result in desired therapeutic effect. Hence, optimized exosomes can be developed via various engineering methods such as pharmacological compound preconditioned MSCs, genetically modified MSCs, or miRNA-loaded exosomes and peptide tagged exosomes to improve the targeting and therapeutic effects of exosomes. The biological characteristics, therapeutic potential, and optimizing strategy of exosomes will be described in our review.http://dx.doi.org/10.1155/2021/5579904 |
| spellingShingle | Xianyun Wang Yida Tang Zhao Liu Yajuan Yin Quanhai Li Gang Liu Baoyong Yan The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction Stem Cells International |
| title | The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction |
| title_full | The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction |
| title_fullStr | The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction |
| title_full_unstemmed | The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction |
| title_short | The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction |
| title_sort | application potential and advance of mesenchymal stem cell derived exosomes in myocardial infarction |
| url | http://dx.doi.org/10.1155/2021/5579904 |
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