Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host’s physi...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9734845 |
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| author | Lucrecia Carrera-Quintanar Rocío I. López Roa Saray Quintero-Fabián Marina A. Sánchez-Sánchez Barbara Vizmanos Daniel Ortuño-Sahagún |
| author_facet | Lucrecia Carrera-Quintanar Rocío I. López Roa Saray Quintero-Fabián Marina A. Sánchez-Sánchez Barbara Vizmanos Daniel Ortuño-Sahagún |
| author_sort | Lucrecia Carrera-Quintanar |
| collection | DOAJ |
| description | Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host’s physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases. |
| format | Article |
| id | doaj-art-8a2fcfc1896a4d7c8a3113902a11cbaf |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8a2fcfc1896a4d7c8a3113902a11cbaf2025-08-20T02:09:18ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/97348459734845Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory DiseasesLucrecia Carrera-Quintanar0Rocío I. López Roa1Saray Quintero-Fabián2Marina A. Sánchez-Sánchez3Barbara Vizmanos4Daniel Ortuño-Sahagún5Universidad de Guadalajara, Laboratorio de Ciencias de los Alimentos, Departamento de Reproducción Humana, Crecimiento y Desarrollo Infantil, CUCS, Guadalajara, JAL, MexicoUniversidad de Guadalajara, Laboratorio de Investigación y Desarrollo Farmacéutico, Departamento de Farmacobiología, CUCEI, Guadalajara, JAL, MexicoUniversidad Nacional Autónoma de México, Instituto Nacional de Pediatría, Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Mexico City, MexicoUniversidad de Guadalajara, Laboratorio de Investigación y Desarrollo Farmacéutico, Departamento de Farmacobiología, CUCEI, Guadalajara, JAL, MexicoUniversidad de Guadalajara, Laboratorio de Evaluación del Estado Nutricio, Departamento de Reproducción Humana, Crecimiento y Desarrollo Infantil, CUCS, Guadalajara, JAL, MexicoUniversidad de Guadalajara, Laboratorio de Neuroinmunobiología Molecular, Instituto de Investigación en Ciencias Biomédicas (IICB), CUCS, Guadalajara, JAL, MexicoGut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host’s physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases.http://dx.doi.org/10.1155/2018/9734845 |
| spellingShingle | Lucrecia Carrera-Quintanar Rocío I. López Roa Saray Quintero-Fabián Marina A. Sánchez-Sánchez Barbara Vizmanos Daniel Ortuño-Sahagún Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases Mediators of Inflammation |
| title | Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases |
| title_full | Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases |
| title_fullStr | Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases |
| title_full_unstemmed | Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases |
| title_short | Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases |
| title_sort | phytochemicals that influence gut microbiota as prophylactics and for the treatment of obesity and inflammatory diseases |
| url | http://dx.doi.org/10.1155/2018/9734845 |
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