Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases

Autoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked to systemic inflammation, oxidative stress, and apoptosis, wh...

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Main Authors: Daniel Galeano-Sánchez, Victoria Morales-González, Diana M. Monsalve, Carolina Ramırez-Santana, Yeny Acosta-Ampudia
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Translational Autoimmunity
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589909024000236
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author Daniel Galeano-Sánchez
Victoria Morales-González
Diana M. Monsalve
Carolina Ramırez-Santana
Yeny Acosta-Ampudia
author_facet Daniel Galeano-Sánchez
Victoria Morales-González
Diana M. Monsalve
Carolina Ramırez-Santana
Yeny Acosta-Ampudia
author_sort Daniel Galeano-Sánchez
collection DOAJ
description Autoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked to systemic inflammation, oxidative stress, and apoptosis, which contribute to the development of ADs.This review examines the impact of air pollutants, including particulate matter, silica, and TCDD, by analyzing epidemiological studies, animal models, and in vitro assays. It focuses on how air pollution disrupts the immune system, leading to apoptosis, increased oxidative stress, cytokine production, autoantigen release, autoantibody production, and autoreactivity, which are particularly significant in ADs like rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis. In essence, this approach aims to provide a profound understanding of how exposure to air pollution can initiate or contribute to ADs, offering potential avenues for more targeted preventive and therapeutic strategies.
format Article
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institution DOAJ
issn 2589-9090
language English
publishDate 2024-12-01
publisher Elsevier
record_format Article
series Journal of Translational Autoimmunity
spelling doaj-art-8a2fb64544374a8ea2002bd85dea9c892025-08-20T02:49:55ZengElsevierJournal of Translational Autoimmunity2589-90902024-12-01910025310.1016/j.jtauto.2024.100253Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseasesDaniel Galeano-Sánchez0Victoria Morales-González1Diana M. Monsalve2Carolina Ramırez-Santana3Yeny Acosta-Ampudia4Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogota, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogota, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogota, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogota, ColombiaCorresponding author.; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad Del Rosario, Bogota, ColombiaAutoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked to systemic inflammation, oxidative stress, and apoptosis, which contribute to the development of ADs.This review examines the impact of air pollutants, including particulate matter, silica, and TCDD, by analyzing epidemiological studies, animal models, and in vitro assays. It focuses on how air pollution disrupts the immune system, leading to apoptosis, increased oxidative stress, cytokine production, autoantigen release, autoantibody production, and autoreactivity, which are particularly significant in ADs like rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis. In essence, this approach aims to provide a profound understanding of how exposure to air pollution can initiate or contribute to ADs, offering potential avenues for more targeted preventive and therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2589909024000236Autoimmune diseasesAir pollutionInflammationParticulate matterSilicaTCDD
spellingShingle Daniel Galeano-Sánchez
Victoria Morales-González
Diana M. Monsalve
Carolina Ramırez-Santana
Yeny Acosta-Ampudia
Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
Journal of Translational Autoimmunity
Autoimmune diseases
Air pollution
Inflammation
Particulate matter
Silica
TCDD
title Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
title_full Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
title_fullStr Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
title_full_unstemmed Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
title_short Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases
title_sort airborne culprits a comprehensive review of pm silica and tcdd in autoimmune diseases
topic Autoimmune diseases
Air pollution
Inflammation
Particulate matter
Silica
TCDD
url http://www.sciencedirect.com/science/article/pii/S2589909024000236
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AT carolinaramırezsantana airborneculpritsacomprehensivereviewofpmsilicaandtcddinautoimmunediseases
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