Expression and molecular insights of lima1 in cholangiocarcinoma
Lim Domain and Actin Binding protein1 (lima1) influence cancer cell function. Thus far, functional role of lima1 in cholangiocarcinoma remains unknown. We used public databases, in vitro experiments, and multi-omics analysis to investigate the Lima1 in cholangiocarcinoma. Our results showed that lim...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cell Adhesion & Migration |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336918.2024.2383068 |
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| _version_ | 1850129021929521152 |
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| author | Halmurat Obulkasim Ailiya Adili Yu Liu Shaobin Duan |
| author_facet | Halmurat Obulkasim Ailiya Adili Yu Liu Shaobin Duan |
| author_sort | Halmurat Obulkasim |
| collection | DOAJ |
| description | Lim Domain and Actin Binding protein1 (lima1) influence cancer cell function. Thus far, functional role of lima1 in cholangiocarcinoma remains unknown. We used public databases, in vitro experiments, and multi-omics analysis to investigate the Lima1 in cholangiocarcinoma. Our results showed that lima1 expression is significantly upregulated and high levels of lima1 are significantly associated with vascular invasion in cholangiocarcinoma. Furthermore, lima1 knocking out inhibits the RBE cell invasion. Multi-omics data suggest that lima1 affect a broad spectrum of cancer related pathways, promoting tumor progression and metastatic ability in cholangiocarcinoma. This study provides insights into molecular associations of lima1 with tumorigenesist and establishes a preliminary picture of the correlation network in cholangiocarcinoma. |
| format | Article |
| id | doaj-art-8a2f3f9dc9114105909aae29b7be2228 |
| institution | OA Journals |
| issn | 1933-6918 1933-6926 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj-art-8a2f3f9dc9114105909aae29b7be22282025-08-20T02:33:07ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262024-12-0118111410.1080/19336918.2024.2383068Expression and molecular insights of lima1 in cholangiocarcinomaHalmurat Obulkasim0Ailiya Adili1Yu Liu2Shaobin Duan3Department of General Surgery, Hospital of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, ChinaBiology Groupe, Hansoh Biology Group Co. Ltd, Shanghai, ChinaDepartment of General Surgery, Hospital of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, ChinaDepartment of General Surgery, Hospital of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi, ChinaLim Domain and Actin Binding protein1 (lima1) influence cancer cell function. Thus far, functional role of lima1 in cholangiocarcinoma remains unknown. We used public databases, in vitro experiments, and multi-omics analysis to investigate the Lima1 in cholangiocarcinoma. Our results showed that lima1 expression is significantly upregulated and high levels of lima1 are significantly associated with vascular invasion in cholangiocarcinoma. Furthermore, lima1 knocking out inhibits the RBE cell invasion. Multi-omics data suggest that lima1 affect a broad spectrum of cancer related pathways, promoting tumor progression and metastatic ability in cholangiocarcinoma. This study provides insights into molecular associations of lima1 with tumorigenesist and establishes a preliminary picture of the correlation network in cholangiocarcinoma.https://www.tandfonline.com/doi/10.1080/19336918.2024.2383068Cell invasioncholangiocarcinomamulti-omicsLim Domain and actin binding protein1 (lima1 or EPLIN)Tumorigenesis |
| spellingShingle | Halmurat Obulkasim Ailiya Adili Yu Liu Shaobin Duan Expression and molecular insights of lima1 in cholangiocarcinoma Cell Adhesion & Migration Cell invasion cholangiocarcinoma multi-omics Lim Domain and actin binding protein1 (lima1 or EPLIN) Tumorigenesis |
| title | Expression and molecular insights of lima1 in cholangiocarcinoma |
| title_full | Expression and molecular insights of lima1 in cholangiocarcinoma |
| title_fullStr | Expression and molecular insights of lima1 in cholangiocarcinoma |
| title_full_unstemmed | Expression and molecular insights of lima1 in cholangiocarcinoma |
| title_short | Expression and molecular insights of lima1 in cholangiocarcinoma |
| title_sort | expression and molecular insights of lima1 in cholangiocarcinoma |
| topic | Cell invasion cholangiocarcinoma multi-omics Lim Domain and actin binding protein1 (lima1 or EPLIN) Tumorigenesis |
| url | https://www.tandfonline.com/doi/10.1080/19336918.2024.2383068 |
| work_keys_str_mv | AT halmuratobulkasim expressionandmolecularinsightsoflima1incholangiocarcinoma AT ailiyaadili expressionandmolecularinsightsoflima1incholangiocarcinoma AT yuliu expressionandmolecularinsightsoflima1incholangiocarcinoma AT shaobinduan expressionandmolecularinsightsoflima1incholangiocarcinoma |