Case Report: Metastatic colorectal cancer with ALK–CEP44 fusion and rapid resistance development

Case Report: Metastatic colorectal cancer with ALK–CEP44 fusion and rapid resistance development

BackgroundColorectal cancer rarely harbors rearrangements in the ALK gene, and the therapeutic significance of non-canonical or functionally unclear ALK fusions remains poorly defined. We report a case of metastatic CRC with an ALK–CEP44 fusion not previously described in this tumor type, associated...

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Bibliographic Details
Main Authors: Silvan Hofmann, Claudine Egger, Silke Potthast, Martin Zoche, Andreas Wicki, Tarun Mehra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
ALK gene mutation
targeted therapy
drug resistance
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1613235/full
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