Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste

In this study, two strains of Penicillium chrysogenum JSPP6_1 and GJY1_3 were isolated from naturally fermented soybean paste. In order to understand the potential role of the two strains in the fermentation of soybean paste, both strains were used for fermenting soybean paste, respectively. The fer...

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Main Authors: Xiaodong Sun, Hong Yang, Guangwei Huo, Linlin Li, Guozhong Lyu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1570939/full
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author Xiaodong Sun
Hong Yang
Guangwei Huo
Linlin Li
Guozhong Lyu
author_facet Xiaodong Sun
Hong Yang
Guangwei Huo
Linlin Li
Guozhong Lyu
author_sort Xiaodong Sun
collection DOAJ
description In this study, two strains of Penicillium chrysogenum JSPP6_1 and GJY1_3 were isolated from naturally fermented soybean paste. In order to understand the potential role of the two strains in the fermentation of soybean paste, both strains were used for fermenting soybean paste, respectively. The fermentation period was 45 days, with samples taken every 5 days. Protease activities of GJY1_3 and JSPP6_1 reached their maximum value on the 15th day of fermentation, 108.95 ± 6.38 and 70.79 ± 2.13 U/mL, respectively. Lipase activities of JSPP6_1 reached the maximum at the 15th day of fermentation (14.52 ± 0.68 U/mL), while that of GJY1_3 reached the maximum at the 20th day of fermentation (7.41 ± 0.75 U/mL). Samples were taken for the metabolomic study on day 15 of fermentation. Fifty-three different metabolites were obtained, of which 33 were known, including seven amino acids, 18 organic acids and anhydrides, as well as a small amounts of sugars, glycolic acids and alcohols. Seventeen metabolic pathways were identified, of which six pathways were significant. The results showed that JSPP6_1 could produce more lipase, and the relative levels of various organic acids were higher in JSPP6_1. GJY1_3 may produce more protease, the relative contents of various amino acids being very higher in GJY1_3, including glutamic acid and glutamine, which are flavor amino acids. Both strains showed obvious functional differences in fermenting soybean paste.
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spelling doaj-art-8a2b922c692f47b7a538c4fd06db76ba2025-08-20T03:12:32ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15709391570939Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean pasteXiaodong SunHong YangGuangwei HuoLinlin LiGuozhong LyuIn this study, two strains of Penicillium chrysogenum JSPP6_1 and GJY1_3 were isolated from naturally fermented soybean paste. In order to understand the potential role of the two strains in the fermentation of soybean paste, both strains were used for fermenting soybean paste, respectively. The fermentation period was 45 days, with samples taken every 5 days. Protease activities of GJY1_3 and JSPP6_1 reached their maximum value on the 15th day of fermentation, 108.95 ± 6.38 and 70.79 ± 2.13 U/mL, respectively. Lipase activities of JSPP6_1 reached the maximum at the 15th day of fermentation (14.52 ± 0.68 U/mL), while that of GJY1_3 reached the maximum at the 20th day of fermentation (7.41 ± 0.75 U/mL). Samples were taken for the metabolomic study on day 15 of fermentation. Fifty-three different metabolites were obtained, of which 33 were known, including seven amino acids, 18 organic acids and anhydrides, as well as a small amounts of sugars, glycolic acids and alcohols. Seventeen metabolic pathways were identified, of which six pathways were significant. The results showed that JSPP6_1 could produce more lipase, and the relative levels of various organic acids were higher in JSPP6_1. GJY1_3 may produce more protease, the relative contents of various amino acids being very higher in GJY1_3, including glutamic acid and glutamine, which are flavor amino acids. Both strains showed obvious functional differences in fermenting soybean paste.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1570939/fullPenicillium chrysogenumsingle strain fermentationprotease activitylipase activitymetabolomics
spellingShingle Xiaodong Sun
Hong Yang
Guangwei Huo
Linlin Li
Guozhong Lyu
Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
Frontiers in Microbiology
Penicillium chrysogenum
single strain fermentation
protease activity
lipase activity
metabolomics
title Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
title_full Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
title_fullStr Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
title_full_unstemmed Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
title_short Study on enzyme activities and metabolomics of two Penicillium chrysogenum strains during fermentation of soybean paste
title_sort study on enzyme activities and metabolomics of two penicillium chrysogenum strains during fermentation of soybean paste
topic Penicillium chrysogenum
single strain fermentation
protease activity
lipase activity
metabolomics
url https://www.frontiersin.org/articles/10.3389/fmicb.2025.1570939/full
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AT guangweihuo studyonenzymeactivitiesandmetabolomicsoftwopenicilliumchrysogenumstrainsduringfermentationofsoybeanpaste
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